Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
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Table 1. Heart weight, body weight and biochemical data of wildtype and ScCKmit -/- mice<br />
Wildtype<br />
(n=9)<br />
ScCKmit -/-<br />
(n=11)<br />
BW<br />
(g)<br />
29.2±0.8<br />
28.4±1.1<br />
LV<br />
(mg)<br />
HW/BW<br />
(mg/g)<br />
Protein<br />
(mg Pr/mg WW)<br />
<strong>Creatine</strong><br />
(mM)<br />
CS<br />
(IU/mg Pr)<br />
LDH<br />
(IU/mg Pr)<br />
Crea.-Trans<br />
(Units of O.D.)<br />
111±3 4.9±0.1 0.147±0.005 18.3±1.2 1.13±0.11 0.48±0.01 27.4±3.3<br />
101±6 5.0±0.2 0.141±0.006 18.0±1.2 1.16±0.06 0.51±0.02 24.3±3.9<br />
Values are means±S.E.M.; BW=body weight; LV=left ventricular weight; HW/BW=heart weight <strong>to</strong> body weight ratio; WW=wet weight;<br />
Pr=protein; CS=citrate synthase; LDH=lactate dehydrogenase; Crea.-Trans.=Na 2+ -<strong>Creatine</strong>-Cotransporter, measured in arbitray units of optical<br />
density
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