Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
Mitochondrial Creatine Kinase is Critically Necessary to Maintain ...
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MS H-00800-2001-R1<br />
Table 3. Isovolumic left ventricular contractile performance at baseline, during increased<br />
work and during recovery of wildtype and ScCKmit -/- hearts<br />
EDP (mmHg)<br />
DevP (mmHg)<br />
RPP<br />
(mmHg/min)<br />
Wildtype<br />
ScCKmit -/-<br />
Wildtype<br />
ScCKmit -/-<br />
Wildtype<br />
ScCKmit -/-<br />
+dP/dt (mmHg/s) Wildtype<br />
ScCKmit -/-<br />
-dP/dt (mmHg/s) Wildtype<br />
ScCKmit -/-<br />
Baseline<br />
HR=420 -1<br />
[Ca 2+ ]=2.0 mM<br />
7±1<br />
8±1<br />
81±4<br />
80±2<br />
34800±1900<br />
34400±1200<br />
3100±100<br />
3100±100<br />
2400±200<br />
2500±100<br />
Increased Work<br />
HR=600 -1<br />
[Ca 2+ ]=4.0 mM<br />
12±2<br />
11±1<br />
78±5<br />
89±4<br />
47000±3000<br />
53200±2300<br />
3400±200<br />
3600±200<br />
3200±300<br />
3400±300<br />
Recovery<br />
HR=420 -1<br />
[Ca 2+ ]=2.0 mM<br />
13±3<br />
12±4<br />
62±3<br />
68±3<br />
25900±1400<br />
28100±1300<br />
2300±100<br />
2400±200<br />
1600±100<br />
1700±200<br />
Values are mean±S.E.M.; HR, heart rate; [Ca 2+ ], calcium concentration in the perfusate. For<br />
details regarding indices of LV performance see Methods. There were no significant differences<br />
among the two groups of hearts at baseline, during increased work or during recovery for any<br />
measure of cardiac function.<br />
24
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