American Chemistry Council/Thiuram Test Plan & Robust Summary

Date: 28-SEP-2001
5. Toxicity ID: 97-77-8
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5.2 Corrosiveness and Irritation
5.2.1 Skin Irritation
Species: rabbit
Concentration:
Exposure:
Exposure Time:
Number of
Animals:
PDII:
Result: not irritating
EC classificat.: not irritating
Method: other: according to 49 CFR 173.240 (DOT, USA)
Year: GLP: no
Test substance: as prescribed by 1.1 - 1.4
Remark: Six rabbits were exposed for four hours to the test
substance. In 48 hours observation no effects on the skin
were observed.
Source: Akzo Nobel Chemicals b.v. Amersfoort
5.2.2 Eye Irritation
Species: rabbit
Concentration:
Dose:
Exposure Time:
Comment:
Number of
Animals:
Result: slightly irritating
EC classificat.: not irritating
Method:
Year: GLP: no
Test substance: as prescribed by 1.1 - 1.4
Remark: 0.1 gram test material was placed in the conjunctival sac of
one eye of each of 6 rabbits, the other eye serving as
control. In three of the treated animals the eye was washed
20-30 seconds after exposure, in the other animals the eyes
remained unwashed.
No effects were observed in the washed eyes. The unwashed
eyes showed the material to be slightly irritating only.
Source: Akzo Nobel Chemicals b.v. Amersfoort
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