American Chemistry Council/Thiuram Test Plan & Robust Summary

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Date: 28-SEP-2001
5. Toxicity ID: 97-77-8
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5.6 Genetic Toxicity 'in Vivo'
Type: Cytogenetic assay
Species: rat Sex: female
Strain: Wistar
Route of admin.: other: two groups oral feed and one group oral gavage
Exposure period: 5 days (low and mid dose group), once (high dose group)
Doses: 350, 750 mg/kg/day (feed) and 3300 mg/kg/day (gavage)
Result:
Method: other
Year: GLP: no data
Test substance: no data
Remark: Animals were killed 24 hours after treatment. Minimum of 100
metaphases were scored per animal. Concluded to be
non-clastogenic.
Source: Akzo Nobel Chemicals b.v. Amersfoort
(22)
Type: Drosophila SLRL test
Species: Drosophila melanogaster Sex:
Strain:
Route of admin.:
Exposure period:
Doses: 3.7-12.3 mg/ml
Result:
Method:
Year: GLP:
Test substance:
Remark: No details given. Test material was negative, when tested up
to 9 days after the treatments.
Source: Akzo Nobel Chemicals b.v. Amersfoort
(23)
Type: Drosophila SLRL test
Species: Drosophila melanogaster Sex:
Strain:
Route of admin.:
Exposure period:
Doses:
Result:
Method:
Year: GLP:
Test substance:
Remark: Result: negative. No further details (eg. concentrations)
were given.
Source: Akzo Nobel Chemicals b.v. Amersfoort