American Chemistry Council/Thiuram Test Plan & Robust Summary
American Chemistry Council/Thiuram Test Plan & Robust Summary
American Chemistry Council/Thiuram Test Plan & Robust Summary
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- 19/23 -<br />
Date: 28-SEP-2001<br />
5. Toxicity ID: 97-77-8<br />
______________________________________________________________________________<br />
5.11 Experience with Human Exposure<br />
Remark: Alcohol intolerance may occur after exposure to<br />
dithiocarbamates.<br />
Cases of contact allergy have been reported in literature.<br />
Tetraethylthiuram disulfide has been used in the treatment<br />
of alcoholism. Articles discussing TETD-, or also called<br />
Disulfiram- or Antabuse-, treatment have been published in<br />
scientific literature. These studies however are not taken<br />
into account for this existing chemicals dossier as they do<br />
not reflect occupational situations and because in alcohol<br />
therapy therapeutically high doses are used, which do not<br />
reflect occupational circumstances. Next to this, in these<br />
studies, combination effects of TETD and alcohol cannot be<br />
ruled out.<br />
Source: Akzo Nobel Chemicals b.v. Amersfoort
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