American Chemistry Council/Thiuram Test Plan & Robust Summary

Date: 28-SEP-2001
5. Toxicity ID: 97-77-8
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5.4 Repeated Dose Toxicity
Species: rat Sex:
Strain:
Route of admin.: oral feed
Exposure period: 2 year
Frequency of
treatment: daily
Post. obs.
period:
Doses: 100, 300, 1000 and 2500 mg/kg diet
Control Group:
Method:
Year: GLP: no data
Test substance: no data
Remark: Doses given correspond to 5, 15, 50 and 125 mg/kg body
weight. Test material was administered via the food. Gross
and microscopic effects and effects on growth and mortality
were seen at the highest level. Lower dosages showed some
effect on growth.
No further details were given.
Source: Akzo Nobel Chemicals b.v. Amersfoort
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5.5 Genetic Toxicity 'in Vitro'
Type: Ames test
System of
testing: TA1535, TA1537, TA1538, TA98, TA100
Concentration: 10 to 100 ug/plate
Cytotoxic Conc.:
Metabolic
activation: with and without
Result: negative
Method: other: acc. to Ames et al.
Year: 1975 GLP: no data
Test substance: no data
Source: Akzo Nobel Chemicals b.v. Amersfoort
Type: Ames test
System of
testing: TA98, TA100, TA1535, TA1537, TA1538
Concentration: 0.5 up to 5000 ug/plate
Cytotoxic Conc.:
Metabolic
activation: with and without
Result: negative
Method: other: according to Ames et al
Year: 1975 GLP: no
Test substance: as prescribed by 1.1 - 1.4
Source: Akzo Nobel Chemicals b.v. Amersfoort
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