Monday PM Human Brain Tumors: Advances in Diagnosis & Prognosis Room 710B 16:30-18:30 Moderators: Sarah J. Nelson & A. Gregory Sorensen 16:30 180. Feature Analysis in SVM-Based Classification of Gliomas Frank G. Zoellner 1 , Kyrre E. Emblem 2,3 , Lothar R. Schad 1 1 Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; 2 Department of Radiology, MGH-HST A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA; 3 The Interventional Center, Oslo University Hospital, Oslo, Norway 16:42 181. In Vivo Detection of IDH Mutations in Gliomas by 1 H-MRS Changho Choi 1 , Sandeep Ganji 1 , Ralph De Berardinis 1 , Zoltan Kovacs 1 , Robert Bachoo 1 , Juan Pascual 1 , Ivan Dimitrov 1,2 , Bruce Mickey 1 , Craig Malloy 1,3 , Elizabeth Maher 1 1 2 3 University of Texas Southwestern Medical Center, Dallas, TX, USA; Philips Medical Systems; VA North Texas Health Care System 16:54 182. Metabolic Characterization of Glioma Populations with Emphasis on Onco-Metabolite 2-Hydroxyglutarate Adam Elkhaled 1 , Llewellyn Jalbert 1 , Hikari Yoshihara 1 , Gabriella Bourne 1 , Joanna Phillips 2 , Soonmee Cha 1 , Susan M. Chang 3 , Radhika Srinivasan 1 , Sarah J. Nelson 1,4 1 Department of Radiology & Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA; 2 Department of Pathology, University of California, San Francisco; 3 Department of Neurological Surgery, University of California, San Francisco; 4 Department of Bioengineering & Therapeutic Sciences, University of California, San Francisco 17:06 183. Presence of 2-Hydroxyglutarate in IDH1 Mutated Low-Grade Glioma using Ex Vivo Proton HR-MAS Spectroscopy Llewellyn Jalbert 1 , Adam Elkhaled 1 , Joanna Phillips 2 , Hikari Yoshihara 1 , Radhika Srinivasan 1 , Gabriela Bourne 1 , 22 Susan Chang 3 , Soonmee Cha 1 , Sarah Nelson 1, 4 1 Department of Radiology & Biomedical Imaging, University of California - San Francisco, San Francisco, CA, USA; 2 Department of Pathology, University of California - San Francisco; 3 Department of Neurological Surgery, University of California - San Francisco; 4 Department of Bioengineering & Therapeutic Sciences, University of California - San Francisco 17:18 184. Detection of 2-Hydroxyglutarate in Mutant Brain Tumors In Vivo using Proton Magnetic Resonance Spectroscopy Rajakumar Nagarajan 1 , Michael Albert Thomas 1 , Whitney B. Pope 1 , Robert M. Prins 2 , Neil Wilson 1 , Noriko Salamon 1 , Linda M. Liau 2 1 2 Radiological Sciences, University of California Los Angeles, Los Angeles, CA, USA; Neurosurgery, University of California Los Angeles 17:30 185. Segmentation of Combinations of Mean Diffusivity & DCE Perfusion Derived CBV in Glioblastoma Multiforme Rishi Awasthi 1 , Ram Kishan Singh Rathore 2 , Jitesh Kumar Singh 2 , Nuzhat Husain 3 , Priyanka Soni 3 , Rohit Kumar Singh 4 , Sanjay Behari 4 , Rakesh Kumar Gupta 1 , Shaleen Kumar 5 1 Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 2 Ma<strong>the</strong>matics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; 3 Pathology, Chatrapati Sahu ji Maharaj Medical University, Lucknow, Uttar Pradesh, India; 4 Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India; 5 Radio<strong>the</strong>rapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, India 17:42 186. Evaluation of Relative CMRO 2 from BOLD & CBF Changes in Hyperoxia: Significant Increase of Oxygen Consumption rate in Glioblastoma Heisoog Kim 1,2 , Ciprian Catana 1 , Kim Mouridsen 1 , Div Bolar 1 , Elizabeth R. Gerstner 3 , Tracy T. Batchelor 3 , Rakesh K. Jain 4 , Bruce R. Rosen 1,2 , A. Gregory Sorensen 1 Radiology, A. A. Martinos Center, Charlestown, MA, USA; 2 HST/NSE, Massachusetts Institute of Technology, Cambridge, MA, USA; 3 Neurology, Massachusetts General Hospital, Boston, MA, USA; 4 Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA 17:54 187. A Simultaneous Measurement of Relative CMRO 2 with MRI & FMISO Uptake with PET in Glioblastoma Heisoog Kim 1 , Ciprian Catana 1 , Grae Arabasz 1 , Div Bolar 1 , Elizabeth R. Gerstner 2 , Tracy T. Batchelor 2 , Rakesh K. Jain 3 , Bruce R. Rosen 1 , A. Gregory Sorensen 1 1 Radiology, A. A. Martinos Center, Charlestown, MA, USA; 2 Neurology, Massachusetts General Hospital, Boston, MA, USA; 3 Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
Monday PM 18:06 188. Multicentre Prospective Classification of Childhood Brain Tumours Based on Metabolite Profiles Derived from 1 H MRS Nigel Paul Davies 1,2 , Simrandip Gill 2,3 , Theodoros N. Arvanitis 3,4 , Doro<strong>the</strong>e Auer 5 , Richard Grundy 6,7 , Franklyn A. Howe 8 , Darren Hargrave 9 , Tim Jaspan 7 , Lesley MacPherson 3 , Kal Natarajan 1,3 , Geoffrey Payne 9,10 , Dawn Saunders 11 , Yu Sun 2,3 , Martin Wilson 2,3 , Andrew C. Peet 2,3 1 Medical Physics, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom; 2 Cancer Sciences, University of Birmingham, Birmingham, United Kingdom; 3 Birmingham Children's Hospital NHS Foundation Trust, Birmingham, United Kingdom; 4 Department of Electrical, Electronic & Computer Engineering, University of Birmingham, Birmingham, United Kingdom; 5 Academic Radiology, University of Nottingham, Nottingham, United Kingdom; 6 Children's Brain Tumour Research Centre, University of Nottingham, Nottingham, United Kingdom; 7 University Hospital Nottingham, Nottingham, United Kingdom; 8 St. George's University of London, London, United Kingdom; 9 Royal Marsden Hospital, London, United Kingdom; 10 Institute of Cancer Research, London, United Kingdom; 11 Great Ormond Street Hospital, London, England, United Kingdom 18:18 189. Segmentation of Tumor Infiltrative & Vasogenic Edema in Brain Tumors using Voxel-Wise Analysis of 11C- Methinonine & FDG PET & its Comparison with Diffusion Tensor Imaging Manabu Kinoshita 1 , Testu Goto 1 , Hideyuki Arita 1 , Naoki Kagawa 1 , Yasunori Fujimoto 1 , Haruhiko Kishima 1 , Yoichi Saitoh 2 , Jun Hatazawa 3 , Naoya Hashimoto 1 , Toshiki Yoshimine 1 1 Neurosurgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; 2 Neuromodulation & Neurosurgery, Center for Advanced Science & Innovation, Osaka University, Suita, Osaka, Japan; 3 Nuclear Medicine & Tracer Kinetics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan 23