Friday AM 17:12 677. Track Density Imaging (TDI): Validation of Super-Resolution Property Fernando Calamante 1,2 , Jacques-Donald Tournier 1,2 , Robin M. Heidemann 3 , Alfred Anwander 3 , Graeme D. Jackson 1,2 , Alan Connelly 1,2 1 Brain Research Institute, Florey Neuroscience Institutes, Heidelberg West, Victoria, Australia; 2 Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia; 3 Max Planck Institute for Human Cognitive & Brain Sciences, Leipzig, Germany 17:24 678. “Tractometry” – Comprehensive Multi-modal Quantitative Assessment of White Matter Along Specific Tracts Sonya Bells 1 , Mara Cercignani 2 , Sean Deoni 3,4 , Yaniv Assaf 5 , Ofer Pasternak 6 , C John Evans 7 , a Leemans 8 , Derek K. Jones 7 1 CUBRIC , School of Psychology, Cardiff, United Kingdom; 2 Santa Lucia Foundation, Neuroimaging Laboratory, Rome, Italy; 3 School of Engineering, Brown University, Providence, RI, USA; 4 Centre of Neuroimaging Sciences-Institute of Psychiatry, King's College, London, United Kingdom; 5 Department of Neurobiology, Tel Aviv University, Tel Aviv, Israel; 6 Brigham & Women's Hospital, Harvard Medical School, Bostan, MA, USA; 7 CUBRIC, School of Psychology, Cardiff, United Kingdom; 8 Image Sciences Institute, University Medical Center Utrecht, Utrecht, Ne<strong>the</strong>rlands 17:36 679. Microstructure Tracking (MicroTrack): An Algorithm for Estimating a Multiscale Hierarchical White Matter Model from Diffusion-Weighted MRI Anthony Jacob Sherbondy 1 , Tim B. Dyrby 2 , Mat<strong>the</strong>w C. Rowe 3 , Maurice Ptito 2,4 , Brian A. Wandell 1 , Daniel C. Alexander 3 1 Psychology Department, Stanford University, Stanford, CA, USA; 2 Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark; 3 Centre for Medical Image Computing, University College London, London, United Kingdom; 4 School of Optometry, University of Montreal, Montreal, Canada 17:48 680. Reliability of Tract-Specific Q-Space Imaging Metrics in Healthy Spinal Cord Torben Schneider 1 , Olga Ciccarelli 2 , Carolina Kachramanoglou 2 , David L. Thomas 2 , Claudia AM Wheeler-Kingshott 1 1 Department of Neuroinflammation, UCL Institute of Neurology, London, United Kingdom; 2 Department of Brain Repair & Rehabilitation, UCL Institute of Neurology, London, United Kingdom Dementia Diagnosis - What Can We Learn from Structural Analysis Room 710B 16:00-18:00 Moderators: Vincent A. Magnotta & Pia C. Maly Sundgren 16:00 681. T 2-VBM is More Sensitive to Alzheimer’s Disease Pathology Than Conventional T 1-VBM Julio Acosta-Cabronero 1 , Lara Z. Diaz-de-Grenu 1 , Joao MS Pereira 1 , George Pengas 1 , Guy B. Williams 1 , Peter J. Nestor 1 1 Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom 16:12 682. HARDI-Based Microstructural Complexity Mapping Reveals Distinct Subcortical & Cortical Grey Matter Changes in Mild Cognitive Impairment & Alzheimer's Disease Hamied Ahmad Haroon 1,2 , Hea<strong>the</strong>r Reynolds 1 , Stephen F. Carter 2,3 , Karl V. Embleton 2,4 , Karl G. Herholz 2,3 , Geoff J. Parker 1,2 1 Imaging Science & Biomedical Engineering, School of Cancer & Enabling Sciences, The University of Manchester, Manchester, England, United Kingdom; 2 Biomedical Imaging Institute, The University of Manchester, Manchester, England, United Kingdom; 3 Wolfson Molecular Imaging Centre, School of Cancer & Enabling Sciences, The University of Manchester, Manchester, England, United Kingdom; 4 School of Psychological Sciences, The University of Manchester, Manchester, England, United Kingdom 16:24 683. Anatomical Connectivity to Assess Brain Tissue Modifications in Alzheimer’s Disease Marco Bozzali 1 , Geoff Parker 2 , Laura Serra 1 , Roberta Perri 3 , Franco Giubilei 4 , Camillo Marra 5 , Carlo Caltagirone 3 , Mara Cercignani 1 1 2 Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; Imaging Science & Biomedical Engineering, University of Manchester, Manchester, United Kingdom; 3 Department of Clinical & Behavioural Neurology, Santa Lucia Foundation, Rome, Italy; 4 5 Department of Neurology, II Faculty of Medicine, “Sapienza” University of Rome, Rome; Institute of Neurology, Università Cattolica, Rome, Italy 16:36 684. Robust High-Dimensional Morphological Metric: Application to <strong>the</strong> ADNI Multi-Centric Dataset Nicolas Robitaille 1 , Abderazzak Mouiha 1 , Simon Duchesne 1,2 1 Centre de recherche Université Laval Robert-Giffard, Québec, QC, Canada; 2 Radiology, Université Laval, Quebec, QC, Canada 16:48 685. Automated Imaging Classification Based On Volumetric Analysis: Application On Primary Progressive Aphasia Andreia Vasconcellos Faria 1,2 , Kyrana Tsapkini 3 , Jennifer Crinion 4 , Hangyi Jiang 1 , Xin Li 1 , Kenichi Oishi 1 , Peter van Zijl 1 , Michael Miller 5 , Argye Hillis 3 , Susumu Mori 1 1 Radiology, Johns Hopkins University, Baltimore, MD, USA; 2 Radiology, State University of Campinas, Campinas, SP, Brazil; 3 Neurology, Johns Hopkins University, Baltimore, MD, USA; 4 Institute of Cognitive Neuroscience, University College London; 5 Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA 94
Thursday PM 17:00 686. Magnetization Transfer Imaging of Individual Beta-Amyloid Plaques in Alzheimer's Disease Mark David Meadowcroft 1 , 2 , Zachary George Herse 1 , James R. Connor 3 , Qing X. Yang 1 1 Radiology - Center for NMR Research, Pennsylvania State University - College of Medicine, Hershey, PA, USA; 2 DMCP - Neuroimaging, Bristol-Myers Squibb, Wallingford, CT, USA; 3 Neurosurgery, Pennsylvania State University - College of Medicine, Hershey, PA, USA 17:12 687. Structural Differences Can Be Found Between MCI Converters & Non-Converters More Than 2 Years Prior to Conversion to AD Gwenaelle Douaud 1 , Ricarda Menke 1 , Achim Gass 2 , Andreas Monsch 3 , Marc Sollberger 2,3 , Anil Rao 4 , Brandon Whitcher 4 , Paul Mat<strong>the</strong>ws 4 , Stephen Smith 1 1 FMRIB Centre, University of Oxford, Oxford, Oxfordshire, United Kingdom; 2 Departments of Neurology & Neuroradiology, University Hospital Basel, Switzerland; 3 Memory Clinic, Department of Geriatrics, University Hospital Basel, Switzerland; 4 GlaxoSmithKline,Clinical Imaging Centre, Hammersmith Hospital London 17:24 688. Multi-Modal MRI Analysis with Disease Specific Spatial Filtering: Initial Testing to Predict Mild Cognitive Impairment Patients Who Convert to Alzheimer’s Disease Kenichi Oishi 1 , Michelle M. Mielke 2 , Andreia V. Faria 1 , Michael I. Miller, Perer C. M. van Zijl 3 , Marilyn Albert 4,5 , Constantine G. Lyketsos 2,5 , Susumu Mori 1,3 1 Radiology, Johns Hopkins University, Baltimore, MD, USA; 2 Psychiatry & Behavioral Sciences, Johns Hopkins University; 3 Kennedy Krieger Institute; 4 Neurology, Johns Hopkins University; 5 The Johns Hopkins Alzheimer’s Disease Research Center 17:36 689. Joint Analysis of Structural & Quantitative Magnetization Transfer MRI For Classification of Alzheimer’s Disease & Normal Aging Giovanni Giulietti 1 , Marco Bozzali 1 , Viviana Figura 1 , Roberta Perri 2 , Camillo Marra 3 , Franco Giubilei 4 , Mara Cercignani 1 1 Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2 Department of Clinical & Behavioural Neurology, Santa Lucia Foundation, Rome, Italy; 3 Institute of Neurology, Cattolica University, Rome, Italy; 4 Department of Neurology, Sapienza University, Rome, Italy 17:48 690. Decreased Brain Stiffness in Alzheimer's Disease Determined by Magnetic Resonance Elastography Mat<strong>the</strong>w C. Murphy 1 , John Huston, III 1 , Clifford R. Jack, Jr. 1 , Kevin J. Glaser 1 , Armando Manduca 1 , Joel P. Felmlee 1 , Richard L. Ehman 1 1 Department of Radiology, Mayo Clinic, Rochester, MN, USA 95