Curriculum Vitae Richard A. Grucza September, 2008 PERSONAL ...

PERSONAL INFORMATION
Place of Birth: Corry, Pennsylvania, USA
Citizenship: USA
Address and Telephone Numbers:
a. Office
Curriculum Vitae
Richard A. Grucza
September, 2008
Department of Psychiatry
Washington University School of Medicine
660 South Euclid Avenue, Box 8134
St. Louis, MO 63110
(314) 362 6535
FAX: (314) 362 4247
e-mail: Rick@wustl.edu
Present Position: Research Assistant Professor (since 2005)
EDUCATION
a. Undergraduate
1984 - 1989 B.S., Chemistry. Rochester Institute of Technology
Rochester, New York
b. Graduate
1989 - 1991 M.S., Chemistry. Pennsylvania State University
University Park, Pennsylvania
1994 - 2000 Ph. D., Molecular Biophysics. Washington University,
Division of Biology and Biomedical Sciences, St. Louis, Missouri
c. Postgraduate
2000 - 2001 Master in Psychiatric Epidemiology, Washington University School of Medicine
St. Louis, Missouri
2000 - 2003 Postdoctoral fellow (Psychiatric Epidemiology and Biostatistics)
Washington University School of Medicine. St. Louis, Missouri
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ACADEMIC POSITIONS / EMPLOYMENT
1991-1994 Assistant Scientist, Pfizer Central Research
Groton, Connecticut
1994-2000 Graduate student / Research Assistant. Washington University
Division of Biology and Biomedical Sciences. St. Louis, Missouri
2000-2003 NIMH Trainee in Biostatistics and Psychiatric Epidemiology. Department of
Psychiatry, Washington University School of Medicine. St. Louis, Missouri.
2003-Pres. Research Instructor to Research Assistant Professor. (2005) Department of
Psychiatry, Washington University School of Medicine.
University and Hospital Appointments and Committees:
2001-present Human Studies Committee (Institutional Review Board) - Continuing Review
Committee. Washington University School of Medicine
2008-present Scholar. Washington University Institute for Public Health.
2009 Ad Hoc grant reviewer, Arts and Sciences Center for Programs Internal
Competition
Honors and Awards:
1989-1991 Pennsylvania State University
Lubrizol Fellowship, Teaching and research assistantships
1994-2000 Washington University, Division of Biology and Biomedical Sciences
Research assistantships and NIH predoctoral training grant
2000-2003 Washington University School of Medicine
Fellow: NIMH postdoctoral training grant
Psychiatric Epidemiology and Biostatistics
2007 Walter G. Klopfer Award for distinguished contribution to the literature in
personality assessment. Presented by the Society for Personality Assessment.
Editorial Responsibilities:
Recent Ad Hoc Reviews: Addiction, Alcohol Research & Health, Comprehensive Psychiatry,
Depression and Anxiety, Drug and Alcohol Dependence, Journal of Adolescence, Journal of
Psychosomatic Research, Journal of Studies on Alcohol, Psychology of Addictive
Behaviors.
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Professional Societies and Organizations:
2001 - Present American Psychopathological Association
2008 - Present Society for Research on Nicotine and Tobacco
Research Support:
a. Governmental
Completed
2003-2008 Principal Investigator - Longitudinal Studies in Personality and Substance Abuse
National Institute on Drug Abuse (K01 DA 016618)
$511,818
Current
20009-2014 Principal Investigator - Alcohol Dependence In African Americans: A Case-
Control Genetic Study (R01 AA017444)
$2,277,850
2007-2009 Co-Investigator - Study Of Addiction: Genetics And Environment.
National Human Genome Research Institute, - Genes and Environment Initiative.
(Laura J. Bierut, PI. HG-U01-004422 )
2008-2013 Co-Investigator - Collaborative Study on the Genetics of Nicotine Dependence
Project 1: Integrative Analyses of Phenotypic and Genetic Data for Nicotine
Dependence. National Cancer Institute. (Laura J. Bierut, PI. P01 CA89392)
2008-2013 Co-Investigator: Genome-Wide Association Study of HIV-1 Host Genetics
Among Injection Drug Users (R01 DA026141, Eric O. Johnson, PI)
2009-2014 Co-Investigator. Genetic Study of Nicotine Dependence in African Americans.
(Laura J. Bierut, PI -- R01 DA25888).
Pending Principal Investigator - Early Substance Use and Addiction: Genes, Environment
and Epidemiology (R21 DA026612-01; First Submission -- June 2008).
Pending Co-Investigator. Washington University SPORE in Lung Cancer, Project 2:
Genetic variation and risk for nicotine addiction, smoking and cancer (NCI P50;
N. Sacccone, PI. Submitted September, 2008).
Pending Co-Investigator. Human genetic variation in smoking and addiction risk. (N.
Saccone, PI. R01 submission for October, 2008).
Teaching Title and Responsibilities:
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2006-present Coursemaster, Epidemiology Seminar II.
2004-present Ad hoc lectures. Epidemiology Seminar, Psychiatric Assessments
2006-07 Mentoring: Research rotation for Dr. Soraya Asadi.
2007 Thesis Committee: Dr. Judson Bliss, Master of Psychiatric Epidemiology thesis.
BIBLIOGRAPHY
a. Peer reviewed manuscripts
1. Réty S., Fütterer K., Grucza RA, Munoz CM, Frazier WA and Waksman,G. pHdependent
self-association of the Src Homology 2 (SH2) domain of the Src-homologous
and collagen-like (SHC) protein. Protein Science 1996, 5: 3
2. Bradshaw JM, Grucza RA, Ladbury JE and Waksman G. Probing the "Two-Pronged Plug
Two-Holed Socket" model for the mechanism of binding of the Src Homology 2 domain to
phosphotyrosyl peptides: A thermodynamic study. Biochemistry 1998, 37: 9083
3. Fütterer, K Wong, J, Grucza RA, Chan AC and Waksman G. Structural basis for Syk
tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure
of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide. Journal of
Molecular Biology 1998, 281: 523
4. Grucza RA, Fütterer K, Chan AC and Waksman G. Thermodynamic study of the binding
of the tandem SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide:
evidence for two conformers. Biochemistry 1999, 38: 5024
5. Grucza RA, Bradshaw JM, Mitakov VM and Waksman G. The role of electrostatic
interactions in SH2 domain recognition: Salt-dependence of tyrosyl-phosphorylated
peptide binding to the tandem SH2 domain of the Syk kinase and the single SH2 domain of
the Src kinase. Biochemistry 2000, 39(33): 10072
6. Grucza RA. Anxiety in major depression. American Journal of Psychiatry, 2001. 158: 9
(letter)
7. Grucza RA, Przybeck TR, Spitznagel EL and Cloninger CR. Personality and depressive
symptoms: A Multi-dimensional analysis. Journal of Affective Disorders, 2003. 74: 123
8. Kumaran S, Grucza RA and Waksman G. The tandem SH2 domain of the syk kinase: A
molecular device to measure interphosphotyrosine distances. Proceedings of the National
Academy of Sciences, 2003. 100: 14828.
9. Grucza RA, Przybeck TR and Cloninger CR. Personality as a mediator of demographic
risk factors for suicide attempts in a community sample. Comprehensive Psychiatry, 2005.
46: 214
10. Cunningham-Williams RM, Grucza RA, Cottler LB, Womack SB, Books SJ, Przybeck
TR, Spitznagel EL and Cloninger, CR. Prevalence and predictors of pathological
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gambling: results from the St. Louis personality, health and lifestyle (SLPHL) study.
Journal of Psychiatric Research, 2005. 39: 377
11. Grucza RA, Cloninger CR, Bucholz KK, Constantino JN, Schuckit MI, Dick DM, Bierut
LJ. Novelty Seeking as a Moderator of Familial Risk for Alcohol Dependence.
Alcoholism: Clinical and Experimental Research, 2006. 30: 1176
12. Grucza RA, Bierut LJ. Cigarette smoking and the risk for alcohol use disorders among
adolescent drinkers. Alcoholism: Clinical and Experimental Research, 2006. 30: 2046.
13. Grucza RA, Przybeck TR, Cloninger CR. Prevalence and correlates of binge eating
disorder in a community sample. Comprehensive Psychiatry, 2007. 48: 124
14. Grucza RA, Abbachi AM, Przybeck TR, Gfroerer JC. Discrepancies in estimates of
prevalence and correlates of substance use and disorders between two national surveys.
Addiction, 2007. 102: 623.
15. Grucza RA, Bierut LJ. Update on COGA findings: Co-occurring risk factors for alcohol
dependence and habitual smoking. Alcohol Research & Health, 2007. 29: 172
16. Grucza RA, Goldberg LR. The Comparative Validity of 11 Modern Personality
Inventories: Predictions of Behavioral Acts, Informant Reports, and Clinical Indicators.
Journal of Personality Assessment, 2007. 89: 167.
17. Agrawal A, Hinrichs AL, Dunn G, Bertelsen S, Dick DM, Saccone SF, Saccone NL,
Grucza RA, Wang JC, Cloninger CR, Edenberg HJ, Foroud T, Hesselbrock V, Kramer J,
Kuperman S, Nurnberger JI Jr., Porjesz B, Schuckit MA, Goate AM, Bierut LJ. Linkage
scan for quantitative traits identifies new regions of interest for substance dependence in
the Collaborative Study on the Genetics of Alcoholism (COGA) Sample. Drug and
Alcohol Dependence, 2008. 93:12.
18. Dick DM, Aliev F, Wang JC, Grucza RA, Schuckit M, Kuperman S, Kramer J, Hinrichs
A, Bertelsen S, Budde JP, Hesselbrock V, Porjesz B, Edenberg H, Bierut LJ, Goate A.
Using dimensional models of externalizing psychopathology to aid in gene identification.
Archives of General Psychiatry 2008. 65:310
19. Grucza RA, Bucholz KK, Rice JP, Bierut LJ. Secular Trends in Alcohol Dependence in
the United States: A Re-Evaluation. Alcoholism: Clinical and Experimental Research.
2008. 32(5):763-70.
20. Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Bertelsen S, Fox L, Grucza RA, Horton WJ,
Kauwe JS, Morgan SD, Saccone NL, Saccone SF, Xuei X, Breslau N, Budde J, Cloninger
CR, Dick DM, Foroud T, Hatsukami D, Hesselbrock V, Johnson EO, Kramer J, Kuperman
S, Madden PAF, Nurnberger J Jr, Pomerleau O, Porjesz B, Reyes O, Schuckit M, Swan G,
Edenberg HJ, Rice JP, Goate AM. Variants in Nicotinic Receptors and Risk for Nicotine
Dependence. Am. J. Psychiatry, 2008. 165:1163.
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21. Grucza RA, Norberg K, Bucholz KK, Bierut LJ. Correspondence between secular changes
in alcohol dependence and age of drinking onset among women in the United States.
.Alcoholism: Clinical and Experimental Research, 2008. 32: 1493.
22. Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs A, Rice JP, Bierut LJ.
Refining disease association signals using cross-population contrasts. BMC Genet, 2008. 9:
58.
23. Grucza RA, Wang JC, Stitzel JA, Hinrichs AL, Saccone SF, Saccone NL, Bucholz KK,
Cloninger CR, Neuman RJ, Budde JP, Fox L, Bertelsen S, Kramer J, Hesselbrock V,
Tischfield J, Nurnberger JI Jr., Almasy L, Porjesz B, Kuperman S, Schuckit MA, Edenberg
HJ, Rice JP, Goate AM, Bierut LJ. Association between the D398N variant of CHRNA5
and cocaine dependence: A risk allele for nicotine dependence is a protective allele for
cocaine dependence. Biological Psychiatry, 2008. 64: 922
24. Wang JC, Grucza RA, Cruchaga C, Hinrichs AL, Bertelsen S, Budde J, Fox L, Goldstein
E, Reyes O, Saccone N., Saccone S., Xuei X., Bucholz K., Kuperman S, Nurnberger JI Jr.,
Rice J., Schuckit MA, Tischfield J., Hesselbrock V, Porjesz B, Edenberg H, Bierut LJ,
Goate AM. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated
with risk for alcohol dependence. Molecular Psychiatry. In Press.
25. McCutcheon VV, Heath AC, Edenberg HJ, Grucza RA, Hesselbrock VM, Kramer JR,
Bierut LJ, Bucholz KK. Alcohol criteria endorsement and psychiatric and drug use
disorders among DUI offenders: Greater severity among women and multiple offenders.
Addict Behav. 2008 Dec 24.
26. Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A,
Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC,
Goate AM, Rice JP, Bierut LJ Multiple distinct risk loci for nicotine dependence identified
by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. Am
J Med Genet B Neuropsychiatr Genet. 2009. In Press..
27. Grucza RA, Norberg, KE, Bierut LJ. Binge drinking among youth and young adults in
the United States: 1979-2006. Journal of the American Academy of Child and Adolescent
Psychiatry. 2009, 48: 7(In Press)
c. Invited publications
28. Grucza RA, Bradshaw JM., Fütterer K, and Waksman G. SH2 domains: from structure
to energetics, a dual approach to the study of structure-function relationships. Medicinal
Research Reviews 1999, 19: 273-293
29. Bradshaw JM,. Grucza RA. and Waksman G. Binding thermodynamics of protein
modules involved in tyrosine kinase signaling pathways. In: The thermodynamics of the
drug- -receptor interaction. R.B. Raffa. Ed., 2001
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30. Grucza RA, Przybeck TR, Cloninger CR. Screening for alcohol problems: an
epidemiological perspective and implications for primary care. Missouri Medicine. 2008:
105: 67.
d. Under review
31. Chen L, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, Wang JC,
Hinrichs AL, Fox L, Goate AM, Rice JP, Bierut LJ. Interplay of Distinct Genetic Risk
Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction (Resubmitted
– April 2009)
32. Wang JC, Cruchaga C Saccone NL, Bertelsen S, Liu P, Budde J, Duan W, Fox L, Grucza
R, Kern J, Mayo K, Reyes O, Rice J, Saccone S, Spiegel N, Steinbach J, Stitzel J,
Anderson M, You M, Stevens V, Bierut L, Goate A. Risk for nicotine dependence and
lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Under Review: Human Molecular Genetics. (Resubmitted, April, 2009)
33. Martins SS, Keyes KM, Storr CL, Zhu H, Grucza RA. Birth cohort trends in lifetime and
past-year nonmedical opioid analgesic use and past-year nonmedical opioid use and pastyear
nonmedical opioid disorders: results from two national surveys. Under Review:
Drug and Alcohol Dependence. Submitted April, 2009
34. Norberg K, Bierut LJ, Grucza RA. The long-term effects of minimum drinking age laws
on alcohol abuse and dependence. . Alcoholism: Clinical and Experimental Research
Submitted: March, 2009.
35. Saccone NL, Saccone SF, Grucza RA, Duan D, Sun L, Wang JC, Breslau N, Fox L,
Hatsukami D, Hinrichs AL, Johnson EO, Rice JP, Steinbach JH, Goate AM, Bierut LJ.
Multiple variants in the CHRNA5-CHRNA3CHRNB4 nicotinic receptor subunit gene
cluster affect risk for nicotine dependence in African-Americans and European-Americans.
Cancer Research. Submitted: February, 2009.
36. Agrawal A, Sartor CE, Lynskey MT, Grant JD, Pergadia ML, Grucza RA, Bucholz KK,
Nelson EC, Madden PAF, Martin NG, Heath AC. Evidence for an interaction between age
at 1 st drink and genetic influences on DSM-IV alcohol dependence symptoms. Alcoholism:
Clinical and Experimental Research Submitted: March, 2009.
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