First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
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TTP: thrombotic thrombocytopenic purpura<br />
• Is an acute life threatening disorder, characterised by:<br />
– microangiopathic haemolytic anaemia<br />
– thrombocytopaenia<br />
– microvascular thrombosis that causes variable degree <strong>of</strong> tissue ischaemia<br />
and infarction<br />
• Rare: 5-11 cases per million people per year<br />
• PE (plasma exchange) decreased mortality from 90% to 10%<br />
• M:F ratio = 1:3<br />
• 5% congenital and 95% acquired<br />
• 20-30% risk <strong>of</strong> recurrence<br />
2
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