First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
First results of the Phase II TITAN trial: anti-von Willebrand ... - Ablynx
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
PD measurement<br />
• RICO/RIPA assay as only suitable assay to assess specifically full<br />
neutralisation <strong>of</strong> (UL)VWF by ALX-0081<br />
Assay Test principle Pro Con<br />
RIPA<br />
RICO<br />
vWF:Act<br />
PFA-100<br />
VWF-mediated aggregation<br />
<strong>of</strong> autologous platelets by<br />
ristocetin<br />
VWF-mediated aggregation<br />
<strong>of</strong> fixed platelets by<br />
ristocetin<br />
Immunoassay with mAb<br />
that interacts with GPIbbinding<br />
region in VWF<br />
High shear flow system to<br />
measure platelet adhesion<br />
and aggregation upon<br />
stimulus<br />
Correlates with preclinical<br />
efficacy <strong>of</strong> ALX-0081 (ACS)<br />
• Demonstrated equivalence<br />
to RIPA<br />
• Can be performed on<br />
frozen samples<br />
Easy, high throughput<br />
• Requires specific<br />
equipment<br />
• Low throughput<br />
• Fresh samples<br />
• Requires specific<br />
equipment<br />
• Low throughput<br />
No inhibition <strong>of</strong> response by<br />
ALX-0081<br />
Easy, high throughput Aspecific: interference <strong>of</strong><br />
comedication<br />
20
Change language