Documentation of published clinical trials and ... - Institut Hiscia

Survival Breast Cancer 5.2.2
Leroi R. (1977) Nachbehandlung des operierten Mamma-Karzinoms mit Viscum album.
[Aftercare of operated breast cancer with Viscum Album.] Helvetica Chirurgica Acta 44, 403–
414.
Study design
Design Retrospective study with 2 groups.
Patients 547 patients with breast cancer, stage I and II from the Lukas Klinik, chosen
according to criteria noted below. The first diagnosis was at least 5 years
previous.
Treatment Group 1: Iscador treatment began within 1 year after operation (on average
25 Iscador series in the first 5 years) and observed for at least 5 years.
Group 2: Patients without Iscador or patients that discontinued therapy
after only a few Iscador series (on average 3 Iscador series in the first 5
years), observation over at least 5 years (n = 228).
Length of study 1963–1975.
Measurement Survival.
Most important results
The 5-year survival rate in the Iscador group 1 with stage I disease is 84% in comparison with
63% in group 2 and in the patients with stage II disease 59% in comparison with 41% (both
differences are statistically significant, p = 0.002). Age distribution and histology were
comparable in both groups. However, there were more patients in group 2 who had received
radical operations and radiotherapy. The good general condition, longer ability to work, good
psychological condition and reduced use of analgesics in the Iscador group 1 were emphasized.
Fig. 1: Course of survival of breast cancer patients with stage I and II disease
with adequate (group 1) and inadequate therapy with Iscador (group 2)
(graph according to Leroi 1977).
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