20.2 Outline a procedure for separating a mixture
20.2 Outline a procedure for separating a mixture
20.2 Outline a procedure for separating a mixture
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<strong>20.2</strong>0 (a) Starting with aniline and assuming that you have 2-aminothiazole available, show how<br />
you would synthesize sulfathiazole. (b) How would you convert sulfathiazole to<br />
succinylsulfathiazole?<br />
Answer:<br />
(a)<br />
(b)<br />
H 2N<br />
NH2<br />
NH2<br />
S<br />
SO2NH<br />
N<br />
(CH 3CO) 2O<br />
S<br />
N<br />
H 2N<br />
O<br />
NHCCH 3<br />
SO 2NH<br />
S<br />
N<br />
2-Aminothiazole<br />
O<br />
O<br />
O<br />
-HCl<br />
O<br />
NHCCH 3<br />
S<br />
N<br />
HOSO2Cl 80℃<br />
(1)dilute HCl,heat<br />
(2)HCO 3 -<br />
O<br />
O<br />
NHCCH 3<br />
SO 2Cl<br />
NH2<br />
SO2NH<br />
S<br />
Sulfathiazole<br />
NHCCH2COOH<br />
SO2NH<br />
S<br />
N<br />
Succinylsulfathiazole<br />
N
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