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Leukemia Lecture Part 2 - Pathology

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The Discovery<br />

of Multiple<br />

Myeloma<br />

Dear Dr. Bence Jones,<br />

Nov. 1, 1845<br />

The tube contains urine of very<br />

high specific gravity. When boiled<br />

it becomes highly opaque. On the<br />

addition of nitric acid it<br />

effervesces, assumes a reddish<br />

hue, and becomes quite clear; but<br />

as it cools assumes the<br />

consistence and appearance<br />

which you see. Heat reliquefies it.<br />

What is it?<br />

Sincerely,<br />

Dr. Thomas Watson

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