Production of Bioactives by Intestinal bacteria:

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Thuricin contains unusual post-translational modifications 8#+2*44#.?## @>.A+.B:./,/-# */CB0+1.D0*2# :,:C6,4E# !&#"%*(#+% !"#)%*(#+% !"#$"%$#&'($)*+),&-./"0$
Trn!# Trn"# Vederas Group Rea et al. PNAS 2010 (1)
Page 1 and 2: Production of Bioactives by Intesti
Page 3 and 4: 1. Bacteriocin production Productio
Page 5 and 6: 1. Bacteriocin production Productio
Page 7 and 8: Class 2 Mode of Action Lipid II Cla
Page 9 and 10: Corr S. C. et.al. PNAS 2007;104:761
Page 11 and 12: 11.6kg Control 11.7kg Probiotic 1 (
Page 13 and 14: Mean Live5 count in ileum = 1.3 x 1
Page 15 and 16: Salivaricin P, 13 kb Natural Varian
Page 17 and 18: Abp118 is encoded on megaplasmid pM
Page 19 and 20: Salivaricin T genes 4433.90 Da 5655
Page 21 and 22: Microbial Production of Bioactives
Page 23: Mary Rea Bacillus thuringiensis Rea
Page 28 and 29: ! # s s s "# s s s Rea et al. PNAS
Page 30 and 31: C. diff log 8 7 6 5 4 3 Faecal ferm
Page 32 and 33: Microbial Production of Bioactives
Page 34 and 35: • Gut microbiota proposed to exer
Page 36 and 37: % Conversion to CLA 90 80 70 60 50
Page 38 and 39: *** LA + B. breve LA BALB/c mice SC
Page 40 and 41: Compositional change is not limited
Page 42 and 43: Increased DHA content of brain foll
Page 44 and 45: Conclusions • Gut flora/probiotic
Page 47 and 48: Trn-! Trn-! T 0h T 5h Trn-! and ! t

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