in the lectures. The Courses and lectures are complemented by extra lectures held by expert (PhD students) of a given topic or invited speakers. The didactic materials are constantly updated. The lecture contents using as source recent (not older than 3 years) state of the art review published on leading journal (Nature, Annu Rev Immunol, Current Opinion in Immunology <strong>et</strong>c).
1.1) Scientific production: 1.1.1) Summary of all original paper. KAROLINSKA INSTITUTET SCIENTIFIC PORTFOLIO 1) La Rocca R, Fulciniti M, Lakshmikanth T, Mesuraca M, Ali TH, Mazzei V, Amodio N, Catalano L, Rotoli B, Ouerfelli O, Grieco M, Gull<strong>et</strong>ta E, Bond HM, Morrone G, Ferrone S, <strong>Carbone</strong> E. Early hematopoi<strong>et</strong>ic zinc finger protein prevents tumor cell recognition by natural killer cells. J Immunol. <strong>2009</strong> Apr 15;182(8):4529-37. 2) Lakshmikanth T, Burke S, Ali TH, Kimpfler S, Ursini F, Ruggeri L, Capanni M, Umansky V, Paschen A, Sucker A, Pende D, Groh V, Biassoni R, Höglund P, Kato M, Shibuya K, Schadendorf D, Anichini A, Ferrone S, Velardi A, Kärre K, Shibuya A, <strong>Carbone</strong>* E, Colucci* F. NCRs and DNAM-1 mediate NK cell recognition and lysis of human and mouse melanoma cell lines in vitro and in vivo. J Clin Invest. <strong>2009</strong> Apr 6. pii: 36022. 3) Terrazzano G, Sica M, Gianfrani C, Mazzarella G, Maurano F, De Giulio B, de Saint-Mezard S, Zanzi D, Maiuri L, Londei M, Jabri B, Troncone R, Auricchio S, Zappacosta S, <strong>Carbone</strong> E. Gliadin regulates the NK-dendritic cell crosstalk by HLA-E surface stabilization. J Immunol. 2007 Jul 1;179(1):372-81. 4) Markasz L, Stuber G, Vanherberghen B, Flaberg E, Olah E, <strong>Carbone</strong> E, Eksborg S, Klein E, Skribek H, Szekely L. Effect of frequently used chemotherapeutic drugs on the cytotoxic activity of human natural killer cells. Mol Cancer Ther. 2007 Feb;6(2):644-54. 5) Wagner CS, Riise GC, Bergstrom T, Karre K, <strong>Carbone</strong> E, Berg L. Increased Expression of Leukocyte Ig-Like Receptor-1 and Activating Role of UL18 in the Response to Cytomegalovirus Infection. J Immunol. 2007 Mar 15;178(6):3536-43. 6) Cerboni C, Achour A, Warnmark A, Mousavi-Jazi M, Sandalova T, Hsu ML, Cosman D, Karre K, <strong>Carbone</strong> E. Spontaneous mutations in the human CMV HLA class I homologue UL18 affect its binding to the inhibitory receptor LIR- 1/ILT2/CD85j. Eur J Immunol. 2006 Mar;36(3):732-41. 7) <strong>Carbone</strong>, E., Neri, P., Mesuraca, M., Fulciniti, M.T., Otsuki, T., Pende, D., Groh, V., Spies, T., Pollio, G., Cosman, D., Catalano, L., Tassone, P. Rotoli, B., and Venuta , S. HLA class I, NKG2D and Natural Cytotoxicity Receptors regulate Multiple Myeloma cell recognition by Natural Killer cells. Blood 2005:105. 8) Terrazzano G, Pisanti S, Grimaldi S, Sica M, Fontana S, <strong>Carbone</strong> E, Zappacosta S, Ruggiero G. Interaction b<strong>et</strong>ween natural killer and dendritic cells: the role of CD40, CD80 and major histocompatibility complex class i