S. pneumoniae

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ROLE OF CLASSICAL MICROBIOLOGY IN PATHOGEN DISCOVERY opagation of an agent facilitates characterization Growth in Vero Cells (10 10 RNA copies/ml) Coronavirus? Paramyxovirus? Coronavirus PCR Electron Microscopy Random Primed Library Differential Display Viral Microarray SARS CoV Paramyxovirus/Yellow Fever virus cPCR Malik Peiris, Hong Kong University
Causation: Implication of microbes in disease Koch, 1890 Microbe occurs in every case of a disease Microbe must be specific for that disease Microbe can be isolated, grown in the laboratory Cause disease after inoculation into animals Some microbes cannot be propagated in vitro Some pathogens may not have animal model systems Rivers, 1937 Adaptive immune response Fredericks & Relman, 1996 Molecular markers Host and environmental factors may influence expression of disease Long-term/distant sequelae may obscure relationship to disease
Page 1 and 2: Metagenomics for Identifying Viral
Page 3 and 4: GROWTH OF THE VIRAL SEQUENCE DATABA
Page 6 and 7: BUSHMEAT TRADE Potential risk for i
Page 8 and 9: INTERNATIONAL TRAVEL Countries with
Page 12 and 13: Causation: Implication of microbes
Page 15 and 16: Influenza-like Illness Sentinel Phy
Page 17 and 18: Epidemiology of H1N1pdm First case:
Page 19 and 20: S. pneumoniae is highly associated
Page 21 and 22: DIFFERENTIAL DIAGNOSIS OF VIRAL HEM
Page 23 and 24: NonParametric results: Binomial tes
Page 25 and 26: PYROSEQUENCING Thomas Briese Sean C
Page 27 and 28: DIFFERENTIAL DIAGNOSIS OF UNEXPLAIN
Page 30 and 31: Date: Fri, 10 Oct 2008 17:00:32 -04
Page 32 and 33: Lujo virus, a new hemorrhagic fever
Page 34 and 35: G1 MOBV, MOPV, IPPYV, LASV, LUJV L
Page 36 and 37: Viruses discovered/characterized at
Page 38 and 39: FO RGOTTEN SCRIPTS Raul Rabadan 53
Page 41 and 42: Immunosignatures of infectious dise
Page 43: www.cii.columbia.edu

S. pneumoniae

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