NIH 2013 Program - University of the Philippines Manila
NIH 2013 Program - University of the Philippines Manila
NIH 2013 Program - University of the Philippines Manila
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LS1. Pentoxifylline <strong>the</strong>rapy among preterm neonates ≤ 1500 grams in reducing<br />
mortality from neonatal sepsis: a double-blind, randomized placebo-controlled<br />
trial<br />
<strong>NIH</strong>-PEER <strong>Program</strong> [Providing an Enabling Environment for Health Research]<br />
Jessamine Mae C Sareno<br />
Pentoxifylline, a xanthine derivative, has raised new interest in neonatal research due to its<br />
immunomodulatory functions and its potential role in reducing mortality from sepsis. Two small<br />
studies done on per-protocol analysis have shown promising results. This larger trial done on an<br />
intention-to-treat basis will try to confirm or refute <strong>the</strong> efficacy <strong>of</strong> pentoxifylline <strong>the</strong>rapy for neonatal<br />
sepsis.<br />
The study determined if <strong>the</strong> use <strong>of</strong> pentoxifylline as an adjunctive <strong>the</strong>rapy for sepsis in preterm<br />
neonates (≤36 weeks) weighing
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