lecture890708 - Workspace
lecture890708 - Workspace
lecture890708 - Workspace
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Triterpenes – Squalene → 2,3-Oxidosqualene<br />
• squalene is oxidised to 2,3-oxidosqualene by squalene oxidase – which is an O 2/FADH 2dependent<br />
enzyme:<br />
• the key oxidant is a peroxyflavin:<br />
O<br />
O O<br />
HN<br />
FADH 2<br />
squalene<br />
H<br />
N O<br />
NR<br />
NH<br />
O<br />
O<br />
O<br />
HN<br />
H<br />
N O<br />
NR<br />
peroxyflavin<br />
NH<br />
squalene<br />
oxidase<br />
O 2 + FADH 2<br />
H 2O + FAD<br />
reductive recycling<br />
O<br />
O<br />
HO<br />
H N<br />
O<br />
H<br />
N O<br />
NR<br />
N<br />
hydroxyflavin<br />
H 2O<br />
2,3-oxidosqualene<br />
O<br />
N<br />
FAD<br />
H<br />
N O<br />
NR<br />
N
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