Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...

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2 Table of contents Class of drug Page number A2RB (Angiotensin 2 Receptor Blockers) 14 ACEI (Angiotensin Converting Enzyme Inhibitors) 13 Analgesics 4 Anti Hep.B/Hep.C drugs 31 Antiarrhythmics 6 Antibiotics 25 Anticoagulants 17 Anticonvulsants 7 Antidepressants 9-10 Antifungals 26 Antimigraine 8 Antipsychotics 8 Antiretrovirals 29-30 Antivirals 29 Anxiolytics / Sedatives/Hypnotics 11-12 Asthma medication 22 Beta Blockers 16 Calcium channel blockers 15 Contraceptives 27 Diuretics 15 Erectile dysfunction medication 28 Fibrates 17 Gastro-intestinal medication 20 Hypoglycaemic Agents 21 Immunosuppressants 23-24 Opioid Substitution Therapy 5 Statins 18-19 Other Drugs Rifampicin Alfuzosin Colchicine Grapefruit Juice 32
3 Legend No clinically significant interaction expected as defined by the Liverpool University website (www.hep-druginteractions.org) Potential interaction (may require close monitoring, alteration of drug dosage or timing of administration) as defined by the Liverpool University website (www.hep-druginteractions.org) These drugs should not be coadministered as defined by the Liverpool University website (www.hep-druginteractions.org) No information available * Information obtained from www.hep-druginteractions.org † Information provided by the VICTRELIS ® (boceprevir) Scientific leaflet $ Drug’s Product Information (Published in MIMs Annual 2011) [drug] Drug concentration ¥ Non exhaustive list of commercial names Association of several molecules k Information from the publication: Kiser et al., Hepatology 2012 a Data from abstracts (complete reference at the bottom of the page) b Information from the publication: Burger et al., Journal of Hepatology 2013 AUC Area Under the Curve BOC Boceprevir DAA Direct Acting Antiviral Agent
Page 1: Updated version: March 2013 Drug Dr
Page 5 and 6: Class of Drug 5 OPIOID SUBSTITUTION
Page 7 and 8: Class of Drug 7 ANTICONVULSANTS Sub
Page 9 and 10: Class of Drug 9 ANTIDEPRESSANTS Sub
Page 11 and 12: Class of Drug 11 ANxIOLyTICS / SEDA
Page 13 and 14: Class of Drug 13 ACEI (ANGIOTENSIN
Page 15 and 16: Class of Drug 15 DIURETICS CALCIUM
Page 17 and 18: Class of Drug 17 ANTICOAGULANTS FIB
Page 19 and 20: Class of Drug 19 STATINS Substrate
Page 21 and 22: Class of Drug 21 HyPOGLyCAEMIC AGEN
Page 23 and 24: Class of Drug 23 IMMUNOSUPPRESSANTS
Page 25 and 26: Class of Drug 25 ANTIBIOTICS Substr
Page 27 and 28: Class of Drug 27 CONTRACEPTIVES Sub
Page 29 and 30: Class of Drug 29 ANTIRETROVIRALS Su
Page 31 and 32: Class of Drug 31 ANTI HEP.B/HEP.C D
Page 33 and 34: 33 No clinically significant intera
Page 35 and 36: disorders Adverse Reactions Common:
Page 37 and 38: Etravirine* (etravirine 200 mg ever
Page 39 and 40: sedatives Midazolam* (oral administ

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