Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
You also want an ePaper? Increase the reach of your titles
YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.
Class of<br />
<strong>Drug</strong><br />
32<br />
OTHER DRUGS<br />
Substrate<br />
class<br />
<strong>Drug</strong> Brand name (non<br />
exhaustive list,<br />
generics not listed).<br />
For a complete list,<br />
please consult<br />
www.bcfi.be or<br />
www.cbip.be<br />
Liverpool University (*) /<br />
Extra-information<br />
Rifampicin Rifadine ® Coadministration<br />
Contraindicated<br />
Alfuzosin Xatral ® Coadministration<br />
Contraindicated<br />
Colchicine Colchicine Opocalcium ® Potential<br />
Interaction<br />
Grapefruit Juice Potential<br />
Interaction*<br />
May [alfuzosin]<br />
which can result<br />
in hypotension*<br />
Significant<br />
increases in<br />
colchicine levels<br />
are expected*<br />
Could increase<br />
BOC<br />
exposure*<br />
Recommendations SmPC/<br />
Scientific Literature<br />
Coadministration not<br />
recommended †<br />
Patients <strong>with</strong> renal or<br />
hepatic impairment<br />
should not be given<br />
colchicine <strong>with</strong> BOC*<br />
smpc: The concomitant use<br />
of BOC <strong>with</strong> rifampicin is not<br />
recommended<br />
CYP pathway(s)<br />
(www.cbip/bcfi.be)<br />
(www.mims.com.au)<br />
CYP3A4<br />
Substrate/<br />
Inhibitor/<br />
Inducer<br />
CYP2B6 / CYP2C9 / induce<br />
CYP2C19 / CYP3A4 /<br />
CYP1A2 / CYP2D6<br />
CYP3A4 Substrate<br />
CYP3A4 Substrate<br />
CYP3A4 Inhibitor
Change language