Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
Drug Drug Interactions with VICTRELIS® (boceprevir) Informative ...
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<strong>Drug</strong> to <strong>Drug</strong> <strong>Interactions</strong> <strong>with</strong> VICTRELIS ® (<strong>boceprevir</strong>)<br />
Class of<br />
<strong>Drug</strong><br />
4<br />
ANALGESICS<br />
Substrate<br />
class<br />
Opioid<br />
NSAID<br />
Narcotic<br />
<strong>Drug</strong> Brand name (non<br />
exhaustive list,<br />
generics not listed).<br />
For a complete list,<br />
please consult<br />
www.bcfi.be or<br />
www.cbip.be<br />
Codeine<br />
Morphine<br />
Fentanyl<br />
Ibuprofen<br />
Paracetamol<br />
Tramadol<br />
Dafalgan Codeine ® ,<br />
Paracod Mylan ® , Panadol<br />
Codeine ® , Algocod ® ,<br />
Nevrine Codeine ®<br />
MS Direct ® , Oramorph ® ,<br />
MS Contin ® , Morphine HCL<br />
Sterop ®<br />
Durogesic ® , Matrifen ® ,<br />
Instanyl ® , Abstral ®<br />
Nurofen ® , Brufen ® ,<br />
Buprophar ® , Dolofin ® ,<br />
Ibumed ® , Malafene ® , ¥<br />
Dafalgan ® , Dolprone ® ,<br />
Panadol ® , Perdolan ® ,<br />
Mersyndol ® , Lemsip ® , ¥<br />
Contramal ® , Dolzam ® ,<br />
Tradonal ® , Tramium ® ,<br />
Zaldiar ® , Pontalsic ®<br />
Liverpool University (*) /<br />
Extra-information<br />
Potential<br />
Interaction<br />
Not Clinically<br />
Significant<br />
Potential<br />
Interaction<br />
Not Clinically<br />
Significant<br />
Not Clinically<br />
Significant<br />
Potential<br />
Interaction<br />
May<br />
[codeine]*<br />
Could<br />
morphine<br />
exposure*<br />
Could<br />
fentanyl<br />
exposure*<br />
May<br />
[tramadol]*<br />
Recommendations SmPC/<br />
Scientific Literature<br />
Monitor carefully for<br />
an extended period<br />
of time. Dosage<br />
adjustment should be<br />
made if warranted*<br />
CYP pathway(s)<br />
(www.cbip/bcfi.be)<br />
(www.mims.com.au)<br />
CYP3A4<br />
Substrate/<br />
Inhibitor/<br />
Inducer<br />
CYP3A4 / CYP2D6 Substrate<br />
CYP2D6<br />
CYP3A4 Substrate<br />
CYP2C9<br />
CYP1A2 / CYP2E1 /<br />
CYP3A4<br />
Substrate<br />
CYP2D6 / CYP3A4 Substrate
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