Synthesis and characterization of linear and cyclic ... - EleA@UniSA

INDEX
CHAPTER 1: INTRODUCTION, 3
1.1 PEPTIDOMIMETICS, 5
1.2 PEPTOIDS: A PROMISING CLASS OF PEPTIDOMIMETICS, 9
1.3 CONFORMATIONAL STUDIES OF PEPTOIDS, 11
1.4 PEPTOIDS’ APPLICATIONS, 14
1.5 PEPTOID SINTHESYS, 39
1.6 SYNTHESYS OF PNA MONOMERS AND OLIGOMERS, 41
1.7 AIMS OF THE WORK, 49
CHAPTER 2: CARBOXYALKYL PEPTOID PNAS: SYNTHESIS AND HYBRIDIZATION PROPERTIES, 51
2.1 INTRODUCTION, 51
2.2. RESULTS AND DISCUSSION, 55
2.3. CONCLUSIONS, 60
2.4 EXPERIMENTAL SECTION, 60
CHAPTER 3: STRUCTURAL ANALYSIS OF CYCLOPEPTOIDS AND THEIR COMPLEXES, 80
3.1 INTRODUCTION, 80
3.2. RESULTS AND DISCUSSION, 85
3.3. CONCLUSIONS, 102
3.4 EXPERIMENTAL SECTION, 103
CHAPTER 4: CATIONIC CYCLOPEPTOIDS AS POTENTIAL MACROCYCLIC NONVIRAL VECTORS, 115
4.1 INTRODUCTION, 115
4.2. RESULTS AND DISCUSSION, 122
4.3. CONCLUSIONS, 125
4.4 EXPERIMENTAL SECTION, 125
CHAPTER 5: COMPLEXATION WITH GD(III) OF CARBOXYETHYL CYCLOPEPTOIDS AS POSSIBLE CONTRAST AGENTS
IN MRI, 132
5.1 INTRODUCTION, 132
5.2 LARIAT ETHER AND CLICK CHEMISTRY, 135
5.3 RESULTS AND DISCUSSION, 141
5.4 EXPERIMENTAL SECTION, 145
CHAPTER 6: CYCLOPEPTOIDS AS MIMETIC OF NATURAL DEFENSINS, 157
6.1 INTRODUCTION, 157
6.2 RESULTS AND DISCUSSION, 162
6.3 CONCLUSIONS, 167
6.5 EXPERIMENTAL SECTION, 167
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