Antiamoebic drugs for treating amoebic colitis - The Cochrane Library

T A B L E O F C O N T E N T S
HEADER . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
PLAIN LANGUAGE SUMMARY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
BACKGROUND . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
OBJECTIVES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
METHODS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5
RESULTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8
Figure 1. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12
Figure 2. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13
Figure 3. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Figure 4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
DISCUSSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17
AUTHORS’ CONCLUSIONS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
REFERENCES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20
CHARACTERISTICS OF STUDIES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32
DATA AND ANALYSES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67
Analysis 1.1. Comparison 1 Alternative drug vs metronidazole, Outcome 1 Clinical failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 72
Analysis 1.2. Comparison 1 Alternative drug vs metronidazole, Outcome 2 Clinical failure: 15 to 60 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73
Analysis 1.3. Comparison 1 Alternative drug vs metronidazole, Outcome 3 Parasitological failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
Analysis 1.4. Comparison 1 Alternative drug vs metronidazole, Outcome 4 Parasitological failure: 15 to 60 days after end
of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 76
Analysis 1.5. Comparison 1 Alternative drug vs metronidazole, Outcome 5 Relapse (ornidazole). . . . . . . . 77
Analysis 1.6. Comparison 1 Alternative drug vs metronidazole, Outcome 6 Adverse events. . . . . . . . . . 78
Analysis 2.1. Comparison 2 Any antiamoebic drug vs placebo, Outcome 1 Clinical failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 79
Analysis 2.2. Comparison 2 Any antiamoebic drug vs placebo, Outcome 2 Parasitological failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 80
Analysis 2.3. Comparison 2 Any antiamoebic drug vs placebo, Outcome 3 Other adverse events. . . . . . . . 81
Analysis 3.1. Comparison 3 Combination regimen vs monotherapy, Outcome 1 Clinical failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Analysis 3.2. Comparison 3 Combination regimen vs monotherapy, Outcome 2 Parasitological failure: 1 to 14 days after
end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 82
Analysis 4.1. Comparison 4 Single dose regimen vs longer regimen, Outcome 1 Clinical failure: 1 to 14 or 15 to 60 days
after end of treatment, combined. . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Analysis 4.2. Comparison 4 Single dose regimen vs longer regimen, Outcome 2 Parasitological failure: 1 to 14 days after
end of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83
Analysis 5.1. Comparison 5 Other antiamoebic drug comparisons, Outcome 1 Clinical failure: 1 to 14 days after end of
treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 84
Analysis 5.2. Comparison 5 Other antiamoebic drug comparisons, Outcome 2 Parasitological failure: 1 to 14 days after end
of treatment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 85
Analysis 6.1. Comparison 6 Subgroup analyses: alternative drug vs metronidazole, Outcome 1 Parasitological failure 15 to
60 days after end of treatment, by clinical category. . . . . . . . . . . . . . . . . . . . . . 86
Analysis 6.2. Comparison 6 Subgroup analyses: alternative drug vs metronidazole, Outcome 2 Parasitological failure 15 to
60 days after end of treatment, by age group. . . . . . . . . . . . . . . . . . . . . . . . 87
Analysis 6.3. Comparison 6 Subgroup analyses: alternative drug vs metronidazole, Outcome 3 Parasitological failure 15 to
60 days after end of treatment, single or mixed intestinal infection. . . . . . . . . . . . . . . . 88
Antiamoebic drugs for treating amoebic colitis (Review)
Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
i