Antiamoebic drugs for treating amoebic colitis - The Cochrane Library

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Huggins 1982 (Continued) Outcomes 1. Parasitological cure: clearance of amoeba from stools on days 2 and 7 after treatment 2. Clinical cure: disappearance of the 4 symptoms recorded at baseline (pain, colic, diarrhoea, and constipation) evaluated on days 2 and 7 after treatment 3. Adverse events: only 2 symptoms (nausea and headache) solicited from participants; laboratory tests were done before and after treatment but results not presented Notes Location: Clinical Hospital of the Federal University of Pernambuco, Brazil Date: 1982 (date of publication only; actual study period not reported) Source of funding: not stated Joshi 1975 Methods Generation of allocation sequence: unclear Allocation concealment: unclear Blinding: open Inclusion of all randomized participants: 100% Participants Number: 60 enrolled and analysed Inclusion criteria: adults with clinical symptoms of intestinal amoebiasis and stool specimens positive for trophozoites or cysts of E. histolytica; laboratory diagnostic method not specified Exclusion criteria: those who received antiamoebic treatment in the previous 1 month, pregnant women, dehydrated patients, and those with hepatic, renal, hematologic or EKG abnormalities Interventions 1. Tinidazole: 600 mg twice daily orally for 5 days 2. Metronidazole: 400 or 800 mg thrice daily orally for 5 days Treatment period was extended to 10 days in both groups when 5 days treatment was inadequate to relieve symptoms or clear the stools of E. histolytica Outcomes 1. Parasitological response: eradication of E. histolytica in stools on day 30 after start of treatment 2. Clinical response: complete or partial relief of symptoms and healing of ulcers on sigmoidoscopy, when carried out 3. Adverse events: voluntary reporting by participants; laboratory tests monitored before and after treatment including haemogram, urinalysis, serum bilirubin, serum transaminases (SGOT, SGPT), alkaline phosphatase, and blood urea Not included in this review: clearance of E. histolytica on day 5 or 10 and day 20 after start of treatment; persistence of clinical symptoms on day 5 or 10 and day 20 after start of treatment Notes Location: Ahmedabad, India Date: 1975 (date of publication only; actual study period not reported) Source of funding: not stated Tinidazole tablets (Fasigyn) were supplied by Pfizer Ltd. Antiamoebic drugs for treating amoebic colitis (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 39
Kapadia 1968 Methods Generation of allocation sequence: unclear Allocation concealment: unclear Blinding: unclear Inclusion of all randomized participants: 100% Participants Number: 50 enrolled and analysed Inclusion criteria: clinical symptoms of intestinal amoebiasis and stool specimens positive for trophozoites and/or cysts of E. histolytica; laboratory diagnostic method was not specified Exclusion criteria: not stated Interventions 1. Chlorhydroxquinoline: 500 mg thrice daily orally for 10 days 2. Di-diiodohydroxyquinoline: 500 mg thrice daily orally for 10 days Not stated if chlorhydroxquinoline and di-diiodohydroxyquinoline were identical in appearance Outcomes 1. Parasitological cure: eradication of E. histolytica from stools at the end of the 10-day treatment period 2. Clinical cure: improvement or disappearance of symptoms at the end of the 10-day treatment period 3. Adverse events: clinical adverse events and liver function test monitored before and after treatment including total bilirubin, serum albumin and globulin, and zinc sulfate Notes Location: Bombay, India Date: 1968 (date of publication only; actual study period not reported) Source of funding: not stated Supply of chlorhydroxquinoline (Quixalin) from Sarabhai Chemicals Karabay 1999 Methods Generation of allocation sequence: unclear Allocation concealment: unclear Blinding: open Inclusion of all randomized participants: 100% Participants Number: 44 enrolled and analysed Inclusion criteria: acute amoebic dysentery and stool specimens positive for E. histolytica cysts and/or trophozoites examined by 0.85% saline water, Lugol solution, and trichrome stain Exclusion criteria: received treatment for diarrhoea in the last 10 days; those with pathogenic bacteria identified in stool culture Interventions 1. Secnidazole: 2 g single oral dose 2. Metronidazole: 750 mg thrice daily orally for 10 days Outcomes 1. Parasitological response: clearance of E. histolytica from stools on days 14 and 21 Not included in this review: mean number of days from start of treatment to resolution of clinical symptoms Notes Location: military hospital in Erzurum, Turkey Date: July 1998 to November 1998 Source of funding: not stated Antiamoebic drugs for treating amoebic colitis (Review) Copyright © 2009 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. 40
Page 1 and 2: Antiamoebic drugs for treating amoe
Page 3 and 4: Analysis 6.4. Comparison 6 Subgroup
Page 5 and 6: Authors’ conclusions Tinidazole i
Page 7 and 8: parasite RNA and DNA (Haque 1995; H
Page 9 and 10: histopathology. We included individ
Page 11 and 12: sponsored trials were conducted wit
Page 13 and 14: (WHO 1969) where ’cure’ was def
Page 15 and 16: Figure 1. Alternative drug vs metro
Page 17 and 18: ness or nausea. No abnormalities in
Page 19 and 20: 4.1. Single-dose secnidazole versus
Page 21 and 22: with some activity against cysts in
Page 23 and 24: A U T H O R S ’ C O N C L U S I O
Page 25 and 26: suspension (two days dosage) in the
Page 27 and 28: el tratamiento de ninos con amibias
Page 29 and 30: Murray 1980 {published data only} M
Page 31 and 32: Sankale 1969 {published data only}
Page 33 and 34: Dans 2006 Dans L, Martinez E. Amoeb
Page 35 and 36: associated with increased expressio
Page 37 and 38: Awal 1979 (Continued) Participants
Page 39 and 40: Botero 1977 (Continued) Exclusion c
Page 41: Donckaster 1964 (Continued) and adu
Page 45 and 46: Mathur 1976 (Continued) Outcomes 1.
Page 47 and 48: Misra 1978 (Continued) 3. Adverse e
Page 49 and 50: Nnochiri 1967 (Continued) haemoglob
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Page 53 and 54: Prasad 1985 (Continued) years of ag
Page 55 and 56: Rossignol 2007 (Continued) Interven
Page 57 and 58: Singh 1977 (Continued) Outcomes 1.
Page 59 and 60: Swami 1977 (Continued) SGPT), and b
Page 61 and 62: (Continued) Baranski 1966 Not RCT B
Page 63 and 64: (Continued) Huggins 1969 Not RCT Hu
Page 65 and 66: (Continued) Padilla 2002 Interventi
Page 67 and 68: (Continued) Simjee 1985 Study popul
Page 69 and 70: Characteristics of studies awaiting
Page 71 and 72: 2 Parasitological failure: 1 to 14
Page 73 and 74: 2.3 Chlorhydroxyquinoline vs diiodo
Page 75 and 76: Comparison 9. Subgroup analyses: an
Page 77 and 78: (... Continued) Study or subgroup A
Page 79 and 80: Analysis 1.4. Comparison 1 Alternat
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Page 83 and 84: Analysis 2.2. Comparison 2 Any anti
Page 85 and 86: Analysis 3.2. Comparison 3 Combinat
Page 87 and 88: Analysis 5.1. Comparison 5 Other an
Page 89 and 90: Analysis 6.1. Comparison 6 Subgroup
Page 91 and 92: (... Continued) Study or subgroup A
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Analysis 6.4. Comparison 6 Subgroup
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(Continued) 24 - - chloroquine oxyt
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(Continued) Department of Medicine,
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(Continued) Africa Egypt Rossignol
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(Continued) Stool microscopy plus s
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(Continued) 6. Not used, but mentio
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(Continued) Padilla 2000 Adequate U
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(Continued) Misra 1974 Malaise: tin
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(Continued) Pehrson 1984 ticipants)
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(Continued) ; metronidazole (4 part
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(Continued) Panidazole Botero 1977
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(Continued) Appendix 12. Adverse ev
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(Continued) Rossignol 2001 Rossigno
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(Continued) Secnidazole vs quinfami
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(Continued) idazole was encountered
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(Continued) Combinationtinidazole a
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(Continued) H I S T O R Y Protocol
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Sensitivity analyses We intended to
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Antiamoebic drugs for treating amoebic colitis - The Cochrane Library

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