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Acino ? Delivering Health

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<strong>Acino</strong>’s development pipeline<br />

Preclinical<br />

development<br />

Oral<br />

Depression<br />

Oral<br />

Iron overload, Thalassemia<br />

TDS<br />

Parkinson’s disease<br />

TDS, Fentanyl 3-day (low load)<br />

EU & US, Pain<br />

Implant, Goserelin Japan<br />

Prostate / Mamma carcinoma<br />

(updated March 2012)<br />

5<br />

Clinical<br />

Phase I / Pilot<br />

Oral<br />

Schizophrenia<br />

Oral<br />

Pain<br />

TDS<br />

Pain<br />

TDS<br />

Alzheimer’s disease<br />

Oral*<br />

CNS/Pain<br />

Oral*<br />

Cancer<br />

Oral dispersible*<br />

Urology<br />

* Projects taken over from Mepha. Several additional projects<br />

in evaluation.<br />

Undisclosed:<br />

Additional customer projects in different stages of development.<br />

Clinical<br />

Phase III / Pivotal<br />

Oral<br />

Schizophrenia<br />

Oxycodone Matrix<br />

Pain<br />

TDS, Rivastigmine USA<br />

Alzheimer’s disease<br />

I.V. injection, Iclaprim<br />

Infection<br />

TDS, Contraceptive; customer<br />

project Bayer <strong>Health</strong>care<br />

Legend:<br />

Oral<br />

Oral<br />

dispersible<br />

TDS Implant<br />

In registration<br />

7 4 4<br />

TDS, Rivastigmine EU<br />

Alzheimer’s disease<br />

Implant, Goserelin 3-month<br />

Prostate carcinoma<br />

Implant, Leuprorelin 1-month<br />

Prostate carcinoma<br />

Implant, Leuprorelin 3-month<br />

Prostate carcinoma<br />

20 Number of <strong>Acino</strong> own projects by stage<br />

NCE (new<br />

chemical entity)<br />

Customer<br />

project<br />

12

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