TOC (PDF) - Journal of Pharmacology and Experimental Therapeutics
TOC (PDF) - Journal of Pharmacology and Experimental Therapeutics
TOC (PDF) - Journal of Pharmacology and Experimental Therapeutics
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VOLUME 261<br />
APRIL 1992<br />
NUMBER 1<br />
ANALGESICS<br />
The<strong>Journal</strong><strong>of</strong><br />
PHARMACOLOGY<br />
AND EXPERIMENTAL THERAPEUTICS<br />
Contents<br />
Naloxone <strong>and</strong> Norbinaltorphimine Administered<br />
Intracerebroventricularly Antagonize Spinal Morphine-<br />
Induced Antinociception in Mice Through the Antianalgesic<br />
Action <strong>of</strong> Spinal Dynorphin A (1-17)<br />
Inhibition <strong>of</strong> the Enkephalin Metabolizing Enzymes by the<br />
First Systemically Active Mixed Inhibitor Prodrug RB 101<br />
Induces Potent Analgesic Responses in Mice <strong>and</strong> Rats<br />
Pharmacodynamics <strong>and</strong> Pharmacokinetics <strong>of</strong> Intravenously<br />
Administered Morphine in Spontaneously Hypertensive <strong>and</strong><br />
Normotensive Wistar-Kyoto Rats<br />
BEHAVIORAL PHARMACOLOGY<br />
Marijuana Smoking: Effect <strong>of</strong> Varying -<br />
Tetrahydrocannabinol Content <strong>and</strong> Number <strong>of</strong> Puffs<br />
Punishment <strong>of</strong> Schedule-Controlled Behavior with -<br />
Carboline Injections: Antagonism <strong>and</strong> Comparisons with<br />
Other Compounds<br />
Discriminative Stimulus Effects <strong>of</strong> Morphine: Effects <strong>of</strong><br />
Training Dose on Agonist <strong>and</strong> Antagonist Effects <strong>of</strong> Mu<br />
Opioids<br />
Differential Influence <strong>of</strong> N-Dealkylation on the Stimulus<br />
Properties <strong>of</strong> Some Opioid Agonists<br />
Alteration <strong>of</strong> General Anesthetic Potency by Agonists <strong>and</strong><br />
Antagonists <strong>of</strong> the Polyamine Binding Site <strong>of</strong> the N-Methyl-<br />
D-Aspartate Receptor<br />
CARDIOVASCULAR PHARMACOLOGY<br />
Predominant Role for Nitric Oxide in the Relaxation Induced<br />
by Acetylcholine in Cat Cerebral Arteries<br />
Effect <strong>of</strong> Ketamine HC1 on Norepinephrine Disposition in<br />
Isolated Ferret Ventricular Myocardium<br />
LY215840, a Potent 5-Hydroxytryptamine (5-HT)2 Receptor<br />
Antagonist, Blocks Vascular <strong>and</strong> Platelet 5-HT2 Receptors<br />
<strong>and</strong> Delays Occlusion in a Rabbit Model <strong>of</strong> Thrombosis<br />
Activation <strong>of</strong> a Relaxation Cascade in Isolated Coronary<br />
Arteries by Brief Electrical Pulses<br />
Baroreflex Changes Produced by Serotonergic or<br />
Catecholaminergic Lesions in the Rat Nucleus Tractus<br />
Solitarius<br />
Different Susceptibility <strong>of</strong> Vasodilator Nerve, Endothelium<br />
<strong>and</strong> Smooth Muscle Functions to Ca4 Antagonists in<br />
Cerebral Arteries<br />
Pressor <strong>and</strong> Renal Vasoconstrictor Effects <strong>of</strong> NGNifroL<br />
Arginine as Affected by Blockade <strong>of</strong> Pressor Mechanisms<br />
Mediated by the Sympathetic Nervous System, Angiotensin,<br />
Prostanoids <strong>and</strong> Vasopressin<br />
On the Mechanism <strong>of</strong> Vasodilating Action <strong>of</strong> Berberine:<br />
Possible Role <strong>of</strong> Inositol Lipid Signaling System<br />
Blythe B. Holmes <strong>and</strong><br />
James M. Fujimoto<br />
F. Noble, J. M. Soleilhac, E. Soroca-<br />
Lucas, S. Turcaud, M. C. Fournie-<br />
Zaluski <strong>and</strong> B. P. Roques<br />
Hemendra N. Bhargava <strong>and</strong><br />
Vincent M. Villar<br />
Julian L. Azorlosa,<br />
Stephen J. Heishman, Maxine L. Stitzer<br />
<strong>and</strong> Judy M. Mahaffey<br />
Kohji Takada, James E. Barrett,<br />
Michael S. Allen, James M. Cook <strong>and</strong><br />
Jonathan L. Katz<br />
Alice M. Young, Mark A. Masaki <strong>and</strong><br />
Changiz Geula<br />
Albert J. Bertalmio,<br />
Fedor Medzihradsky, Gail Winger <strong>and</strong><br />
James H. Woods<br />
Laura C. Daniell<br />
Maria J. Alonso, Mercedes Salaices,<br />
Carlos F. Sanchez-Ferrer <strong>and</strong><br />
Jesus Mann<br />
David J. Cook, Philippe R. Housmans<br />
<strong>and</strong> Duane K. Rorie<br />
Marlene L. Cohen, David W. Robertson,<br />
William E. Bloomquist <strong>and</strong><br />
Harve C. Wilson<br />
Stanley Kalsner<br />
Hiroshi Itoh, Richard H. Alper <strong>and</strong><br />
Ruben D. Bu#{241}ag<br />
Noboru Toda <strong>and</strong> Tomio Okamura<br />
Michael L. Pucci, Lang Lin <strong>and</strong><br />
Alberto Nasjletti<br />
Sergio Bova, Roberto Padrini,<br />
William F. Goldman, Dora M. Berman<br />
<strong>and</strong> Gabriella Cargnelli<br />
146<br />
181<br />
290<br />
114<br />
138<br />
246<br />
278<br />
304<br />
12<br />
101<br />
202<br />
209<br />
225<br />
234<br />
240<br />
318<br />
Contents continued on iv
Contents continued from iii<br />
CELLULAR AND MOLECULAR PHARMACOLOGY<br />
Sequestration <strong>of</strong> Organic Cations by Acidified Hepatic<br />
Endocytic Vesicles <strong>and</strong> Implications for Biliary Excretion<br />
Comparative Action <strong>of</strong> Methylmercury <strong>and</strong> Divalent Inorganic<br />
Mercury on Nerve Terminal <strong>and</strong> Intraterminal Mitochondrial<br />
Membrane Potentials<br />
DRUG METABOLISM AND DISPOSITION<br />
Metabolism Rate <strong>of</strong> Oxodipine in Rats <strong>and</strong> Humans:<br />
Comparison <strong>of</strong> in Vivo <strong>and</strong> in Vitro Data<br />
GASTROINTESTINAL PHARMACOLOGY<br />
Effect <strong>of</strong> Newly Developed Tachykinin Agonist <strong>and</strong><br />
Antagonists on the Guinea Pig Isolated Gallbladder<br />
Transepithelial Transport <strong>of</strong> Oral Cephalosporins by<br />
Monolayers <strong>of</strong> Intestinal Epithelial Cell Line Caco-2: Specific<br />
Transport Systems in Apical <strong>and</strong> Basolateral Membranes<br />
Role <strong>of</strong> the Serotonin3 Receptor in Stress-Induced Defecation<br />
NEUROPHARMACOLOGY<br />
In Vivo Modeling <strong>of</strong> the Pharmacodynamic Interaction<br />
Between Benzodiazepines Which Differ in Intrinsic Efficacy<br />
A Further Evaluation <strong>of</strong> the Effects <strong>of</strong> K Depolarization on<br />
Glutamate-Evoked l3HlDopamine Release from Striatal Slices<br />
Increased Sensitivity to the Anesthetic Effect <strong>of</strong><br />
Phenobarbital in Aging BN/BiRij Rats<br />
Modeling <strong>of</strong> the Effect Site Equilibration Kinetics <strong>and</strong><br />
Pharmacodynamics <strong>of</strong> Racemic Bacl<strong>of</strong>en <strong>and</strong> its Enantiomers<br />
Using Quantitative EEG Effect Measures<br />
Role <strong>of</strong> the ‘y-Aminobutyric Acid Receptor/Chloride Channel<br />
Complex in Tolerance to Ethanol <strong>and</strong> Cross-Tolerance to<br />
Diazepam <strong>and</strong> Pentobarbital<br />
In Vivo Electrophysiological Evidence for a Selective<br />
Modulation <strong>of</strong> N-Methyl-r-Aspartate-Induced Neuronal<br />
Activation in Rat CA3 Dorsal Hippocampus by Sigma<br />
Lig<strong>and</strong>s<br />
Identification <strong>of</strong> Spinal 5-HT1 Binding Sites in the Rat:<br />
Characterization <strong>of</strong> (3HMesulergine Binding<br />
Desensitization <strong>and</strong> Down-Regulation <strong>of</strong> the 5-<br />
Hydroxytryptamine18 Receptor in the Opossum Kidney Cell<br />
Line<br />
Chronic Benzodiazepine Administration. X. Concurrent<br />
Administration <strong>of</strong> the Peripheral-Type Benzodiazepine Lig<strong>and</strong><br />
PKI 1195 Attenuates Chronic Effects <strong>of</strong> Lorazepam<br />
Dihydropyridine- <strong>and</strong> -Conotoxin-Resistant, Neomycin-<br />
Sensitive Calcium Channels Mediate the Depolarization-<br />
Induced Increase in Internal Calcium Levels in Cortical Slices<br />
from Immature Rat Brain<br />
Pyrazole, an Alcohol Dehydrogenase Inhibitor, Has Dual<br />
Effects on N-Methyl-D-Aspartate Receptors <strong>of</strong> Hippocampal<br />
Pyramidal Cells: Agonist <strong>and</strong> Noncompetitive Antagonist<br />
D, <strong>and</strong> D2 Dopamine Receptor Distribution in the Neuroleptic<br />
Nonresponsive <strong>and</strong> Neuroleptic Responsive Lines <strong>of</strong> Mice, A<br />
Quantitative Receptor Autoradiographic Study<br />
Rebecca W. Van Dyke, Esther D. Faber 1<br />
<strong>and</strong> Dirk K. F. Meijer<br />
Michael F. Hare <strong>and</strong> 166<br />
William D. Atchison<br />
J.-P. Flinois, M. Chabin, F. Egros, 381<br />
A. Dufour, I. de Waziers, C. Mas-<br />
Chamberlin <strong>and</strong> P. H. Beaune<br />
Riccardo Patacchini <strong>and</strong> 191<br />
Carlo Alberto Maggi<br />
Ken-Ichi Inui, Michiko Yamamoto <strong>and</strong> 195<br />
Hideyuki Saito<br />
Keiji Miyata, Takeshi Kamato,<br />
Akito Nishida, Hiroyuki Ito,<br />
Hidenobu Yuki, Mayumi Yamano,<br />
Rie Tsutsumi, Yoshinori Katsuyama<br />
<strong>and</strong> Kazuo Honda<br />
297<br />
Jaap W. M<strong>and</strong>ema, Maarten T. Kuck 56<br />
<strong>and</strong> Meindert Danh<strong>of</strong><br />
John F. Bowyer, Glenn D. Newport, 72<br />
George W. Lipe <strong>and</strong> Lynn T. Frame<br />
A. M. Stijnen, M. Danh<strong>of</strong> <strong>and</strong> 81<br />
C. F. A. van Bezooijen<br />
Jaap W. M<strong>and</strong>ema, Come D. Heijligers- 88<br />
Feijen, Erica Tukker,<br />
Albertus G. de Boer <strong>and</strong><br />
Meindert Danh<strong>of</strong><br />
S. J. Mihic, H. Kalant, J.-F. Liu <strong>and</strong> 108<br />
P.H.Wu<br />
Francois P. Monnet, Guy Debonnel <strong>and</strong> 123<br />
Claude de Montigny<br />
M. R. Pranzatelli, J. N. Murthy <strong>and</strong> 161<br />
R. S. Pluchino<br />
Richard C. Pleus <strong>and</strong> David B. Bylund 271<br />
Lawrence G. Miller, Wendy R. Galpern, 285<br />
John J. Byrnes, David J. Greenblatt <strong>and</strong><br />
Richard I. Shader<br />
M. L. Perrier, B. Scatton <strong>and</strong> 324<br />
J. Benavides<br />
Edna F. R. Pereira, Yasco Aracava, 331<br />
Robert S. Aronstam, Eliezer J. Barreiro<br />
<strong>and</strong> Edson X. Albuquerque<br />
Yifang Qian, Barbara Hitzemann <strong>and</strong> 341<br />
Robert Hitzemann<br />
Contents continued on v
Contents continued from iv<br />
Effects <strong>of</strong> N-Methyl-n-Aspartate Receptor Antagonists on<br />
Carbon Monoxide-Induced Brain Damage in Mice<br />
PHARMACOLOGY OF SUBSTANCE ABUSE<br />
Buprenorphine’s Effects on Self-Administration <strong>of</strong> Smoked<br />
Cocaine-Base <strong>and</strong> Orally Delivered Phencyclidine, Ethanol<br />
<strong>and</strong> Saccharin in Rhesus Monkeys -<br />
Discrimination <strong>of</strong> Agonist-Antagonist Opioids in Humans<br />
Trained on a Two-Choice Saline-Hydromorphone<br />
Discrimination<br />
Classical Genetic Analyses <strong>of</strong> Responses to Nicotine <strong>and</strong><br />
Ethanol in Crosses Derived from Long- <strong>and</strong> Short-Sleep Mice<br />
Effects <strong>of</strong> Buprenorphine <strong>and</strong> Other Opioid Agonists <strong>and</strong><br />
Antagonists on Alfentanil- <strong>and</strong> Cocaine-Reinforced<br />
Responding in Rhesus Monkeys<br />
PROSTAGLAND1NS, LEUKOTRIENES AND OTHER EICOSANOIDS<br />
Pharmacological Characterization <strong>of</strong> Potent, Long Acting<br />
Thromboxane Receptor Antagonists, SQ 33,261 <strong>and</strong> SQ<br />
33,552<br />
PULMONARY PHARMACOLOGY<br />
The Relaxant Properties in Guinea Pig Airways <strong>of</strong> S-<br />
Nitrosothiols<br />
Highly Potent Beta-2 Sympathomimetics Convert to Less<br />
Potent Partial Agonists as Relaxants <strong>of</strong> Guinea Pig Tracheae<br />
Maximally Contracted by Carbachol. Comparison <strong>of</strong><br />
Relaxation with Receptor Binding <strong>and</strong> Adenylate Cyclase<br />
Stimulation<br />
RENAL PHARMACOLOGY<br />
Interference with Renal Organic Cation Transport by (-)- <strong>and</strong><br />
(+)-Nicotine at Concentrations Documented in Plasma <strong>of</strong><br />
Habitual Tobacco Smokers<br />
An Investigation <strong>of</strong> the Acute Effect <strong>of</strong> Gentamicin on the<br />
Renal H<strong>and</strong>ling <strong>of</strong> Electrolytes in the Rat<br />
Effect <strong>of</strong> Cyclosporine on Colchicine Secretion by the Kidney<br />
Multidrug Transporter Studied in Vivo<br />
Renin-Angiotensin System Inhibition Reduces Glycine-<br />
Induced Glomerular Hyperfiltration in Conscious Rats<br />
TOXICOLOGY<br />
Toxicity <strong>of</strong> 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in<br />
Primary Cultures <strong>of</strong> Mouse Astrocytes<br />
Relationship to Cytochrome P450 Activity to Clara Cell<br />
Cytotoxicity. I. Histopathologic Comparison <strong>of</strong> the<br />
Respiratory Tract <strong>of</strong> Mice, Rats <strong>and</strong> Hamsters after<br />
Parenteral Administration <strong>of</strong> Naphthalene<br />
Relationship <strong>of</strong> Cytochrome P450 Activity to Clara Cell<br />
Cytotoxicity. II. Comparison <strong>of</strong> Stereoselectivity <strong>of</strong><br />
Naphthalene Epoxidation in Lung <strong>and</strong> Nasal Mucosa <strong>of</strong><br />
Mouse, Hamster, Rat <strong>and</strong> Rhesus Monkey<br />
Impaired Expression <strong>of</strong> Microsomal Cytochrome P450 2C1 1<br />
in Choline-Deficient Rat Liver During the Development <strong>of</strong><br />
Cirrhosis<br />
Hirohisa lshimaru, Akira Katoh,<br />
Hirotaka Suzuki, Taneo Fukuta,<br />
Tsutomu Kameyama <strong>and</strong><br />
Toshitaka Nabeshima<br />
Marilyn E. Carroll,<br />
Gilberto N. Carmona, Susan A. May,<br />
Sherry Buzalsky <strong>and</strong> Christopher Larson<br />
Kenzie L. Preston, Ira A. Liebson <strong>and</strong><br />
George E. Bigelow<br />
Christopher M. de Fiebre <strong>and</strong><br />
Allan C. Collins<br />
Gail Winger, Paul Skjoldager <strong>and</strong><br />
James H. Woods<br />
Don N. Hams, Inge M. Michel,<br />
Harold J. Goldenberg, Karen S. Hartl,<br />
Guy T. Allen, Thomas E. Steinbacher,<br />
William A. Schumacher, Wen-<br />
Ching Han, Steven E. Hall,<br />
David M. Floyd <strong>and</strong> Martin L. Ogletree<br />
Albertine Jansen, Jeffrey Drazen,<br />
John A. Osborne, Robert Brown,<br />
Joseph Loscalzo <strong>and</strong><br />
Jonathan S. Stamler<br />
Horst Lemoine <strong>and</strong> Clemens Overlack<br />
Leo T. Y. Wong, Donald D. Smyth <strong>and</strong><br />
Daniel S. Sitar<br />
J. E. Foster, E. S. Harpur <strong>and</strong><br />
H. 0. Garl<strong>and</strong><br />
K. Vincent Speeg, Alma L. Maldonado.<br />
Julie Liaci <strong>and</strong> Donna Muirhead<br />
Yi-Xin Wang <strong>and</strong> David P. Brooks<br />
Donato A. Di Monte, Ellen Y. Wu,<br />
Louis E. DeLanney, Ian Irwin <strong>and</strong><br />
J. William Langston<br />
Charles G. Plopper, Claus Suverkropp,<br />
Dexter Morin, Susan Nishio <strong>and</strong><br />
Alan Buckpitt<br />
Alan Buckpitt, Michael Buonarati,<br />
Linda Bahnson Avey, Ai Mm Chang,<br />
Dexter Morn <strong>and</strong> Charles G. Flopper<br />
Michael Murray, Elizabeth Cantrill,<br />
Ishita Mehta <strong>and</strong> Ge<strong>of</strong>frey C. Farrell<br />
349<br />
26<br />
62<br />
173<br />
311<br />
131<br />
154<br />
258<br />
21<br />
38<br />
50<br />
96<br />
44<br />
353<br />
364<br />
373
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