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Contents continued from iii CELLULAR AND MOLECULAR PHARMACOLOGY Sequestration of Organic Cations by Acidified Hepatic Endocytic Vesicles and Implications for Biliary Excretion Comparative Action of Methylmercury and Divalent Inorganic Mercury on Nerve Terminal and Intraterminal Mitochondrial Membrane Potentials DRUG METABOLISM AND DISPOSITION Metabolism Rate of Oxodipine in Rats and Humans: Comparison of in Vivo and in Vitro Data GASTROINTESTINAL PHARMACOLOGY Effect of Newly Developed Tachykinin Agonist and Antagonists on the Guinea Pig Isolated Gallbladder Transepithelial Transport of Oral Cephalosporins by Monolayers of Intestinal Epithelial Cell Line Caco-2: Specific Transport Systems in Apical and Basolateral Membranes Role of the Serotonin3 Receptor in Stress-Induced Defecation NEUROPHARMACOLOGY In Vivo Modeling of the Pharmacodynamic Interaction Between Benzodiazepines Which Differ in Intrinsic Efficacy A Further Evaluation of the Effects of K Depolarization on Glutamate-Evoked l3HlDopamine Release from Striatal Slices Increased Sensitivity to the Anesthetic Effect of Phenobarbital in Aging BN/BiRij Rats Modeling of the Effect Site Equilibration Kinetics and Pharmacodynamics of Racemic Baclofen and its Enantiomers Using Quantitative EEG Effect Measures Role of the ‘y-Aminobutyric Acid Receptor/Chloride Channel Complex in Tolerance to Ethanol and Cross-Tolerance to Diazepam and Pentobarbital In Vivo Electrophysiological Evidence for a Selective Modulation of N-Methyl-r-Aspartate-Induced Neuronal Activation in Rat CA3 Dorsal Hippocampus by Sigma Ligands Identification of Spinal 5-HT1 Binding Sites in the Rat: Characterization of (3HMesulergine Binding Desensitization and Down-Regulation of the 5- Hydroxytryptamine18 Receptor in the Opossum Kidney Cell Line Chronic Benzodiazepine Administration. X. Concurrent Administration of the Peripheral-Type Benzodiazepine Ligand PKI 1195 Attenuates Chronic Effects of Lorazepam Dihydropyridine- and -Conotoxin-Resistant, Neomycin- Sensitive Calcium Channels Mediate the Depolarization- Induced Increase in Internal Calcium Levels in Cortical Slices from Immature Rat Brain Pyrazole, an Alcohol Dehydrogenase Inhibitor, Has Dual Effects on N-Methyl-D-Aspartate Receptors of Hippocampal Pyramidal Cells: Agonist and Noncompetitive Antagonist D, and D2 Dopamine Receptor Distribution in the Neuroleptic Nonresponsive and Neuroleptic Responsive Lines of Mice, A Quantitative Receptor Autoradiographic Study Rebecca W. Van Dyke, Esther D. Faber 1 and Dirk K. F. Meijer Michael F. Hare and 166 William D. Atchison J.-P. Flinois, M. Chabin, F. Egros, 381 A. Dufour, I. de Waziers, C. Mas- Chamberlin and P. H. Beaune Riccardo Patacchini and 191 Carlo Alberto Maggi Ken-Ichi Inui, Michiko Yamamoto and 195 Hideyuki Saito Keiji Miyata, Takeshi Kamato, Akito Nishida, Hiroyuki Ito, Hidenobu Yuki, Mayumi Yamano, Rie Tsutsumi, Yoshinori Katsuyama and Kazuo Honda 297 Jaap W. Mandema, Maarten T. Kuck 56 and Meindert Danhof John F. Bowyer, Glenn D. Newport, 72 George W. Lipe and Lynn T. Frame A. M. Stijnen, M. Danhof and 81 C. F. A. van Bezooijen Jaap W. Mandema, Come D. Heijligers- 88 Feijen, Erica Tukker, Albertus G. de Boer and Meindert Danhof S. J. Mihic, H. Kalant, J.-F. Liu and 108 P.H.Wu Francois P. Monnet, Guy Debonnel and 123 Claude de Montigny M. R. Pranzatelli, J. N. Murthy and 161 R. S. Pluchino Richard C. Pleus and David B. Bylund 271 Lawrence G. Miller, Wendy R. Galpern, 285 John J. Byrnes, David J. Greenblatt and Richard I. Shader M. L. Perrier, B. Scatton and 324 J. Benavides Edna F. R. Pereira, Yasco Aracava, 331 Robert S. Aronstam, Eliezer J. Barreiro and Edson X. Albuquerque Yifang Qian, Barbara Hitzemann and 341 Robert Hitzemann Contents continued on v
Contents continued from iv Effects of N-Methyl-n-Aspartate Receptor Antagonists on Carbon Monoxide-Induced Brain Damage in Mice PHARMACOLOGY OF SUBSTANCE ABUSE Buprenorphine’s Effects on Self-Administration of Smoked Cocaine-Base and Orally Delivered Phencyclidine, Ethanol and Saccharin in Rhesus Monkeys - Discrimination of Agonist-Antagonist Opioids in Humans Trained on a Two-Choice Saline-Hydromorphone Discrimination Classical Genetic Analyses of Responses to Nicotine and Ethanol in Crosses Derived from Long- and Short-Sleep Mice Effects of Buprenorphine and Other Opioid Agonists and Antagonists on Alfentanil- and Cocaine-Reinforced Responding in Rhesus Monkeys PROSTAGLAND1NS, LEUKOTRIENES AND OTHER EICOSANOIDS Pharmacological Characterization of Potent, Long Acting Thromboxane Receptor Antagonists, SQ 33,261 and SQ 33,552 PULMONARY PHARMACOLOGY The Relaxant Properties in Guinea Pig Airways of S- Nitrosothiols Highly Potent Beta-2 Sympathomimetics Convert to Less Potent Partial Agonists as Relaxants of Guinea Pig Tracheae Maximally Contracted by Carbachol. Comparison of Relaxation with Receptor Binding and Adenylate Cyclase Stimulation RENAL PHARMACOLOGY Interference with Renal Organic Cation Transport by (-)- and (+)-Nicotine at Concentrations Documented in Plasma of Habitual Tobacco Smokers An Investigation of the Acute Effect of Gentamicin on the Renal Handling of Electrolytes in the Rat Effect of Cyclosporine on Colchicine Secretion by the Kidney Multidrug Transporter Studied in Vivo Renin-Angiotensin System Inhibition Reduces Glycine- Induced Glomerular Hyperfiltration in Conscious Rats TOXICOLOGY Toxicity of 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Primary Cultures of Mouse Astrocytes Relationship to Cytochrome P450 Activity to Clara Cell Cytotoxicity. I. Histopathologic Comparison of the Respiratory Tract of Mice, Rats and Hamsters after Parenteral Administration of Naphthalene Relationship of Cytochrome P450 Activity to Clara Cell Cytotoxicity. II. Comparison of Stereoselectivity of Naphthalene Epoxidation in Lung and Nasal Mucosa of Mouse, Hamster, Rat and Rhesus Monkey Impaired Expression of Microsomal Cytochrome P450 2C1 1 in Choline-Deficient Rat Liver During the Development of Cirrhosis Hirohisa lshimaru, Akira Katoh, Hirotaka Suzuki, Taneo Fukuta, Tsutomu Kameyama and Toshitaka Nabeshima Marilyn E. Carroll, Gilberto N. Carmona, Susan A. May, Sherry Buzalsky and Christopher Larson Kenzie L. Preston, Ira A. Liebson and George E. Bigelow Christopher M. de Fiebre and Allan C. Collins Gail Winger, Paul Skjoldager and James H. Woods Don N. Hams, Inge M. Michel, Harold J. Goldenberg, Karen S. Hartl, Guy T. Allen, Thomas E. Steinbacher, William A. Schumacher, Wen- Ching Han, Steven E. Hall, David M. Floyd and Martin L. Ogletree Albertine Jansen, Jeffrey Drazen, John A. Osborne, Robert Brown, Joseph Loscalzo and Jonathan S. Stamler Horst Lemoine and Clemens Overlack Leo T. Y. Wong, Donald D. Smyth and Daniel S. Sitar J. E. Foster, E. S. Harpur and H. 0. Garland K. Vincent Speeg, Alma L. Maldonado. Julie Liaci and Donna Muirhead Yi-Xin Wang and David P. Brooks Donato A. Di Monte, Ellen Y. Wu, Louis E. DeLanney, Ian Irwin and J. William Langston Charles G. Plopper, Claus Suverkropp, Dexter Morin, Susan Nishio and Alan Buckpitt Alan Buckpitt, Michael Buonarati, Linda Bahnson Avey, Ai Mm Chang, Dexter Morn and Charles G. Flopper Michael Murray, Elizabeth Cantrill, Ishita Mehta and Geoffrey C. Farrell 349 26 62 173 311 131 154 258 21 38 50 96 44 353 364 373
Page 1: VOLUME 261 APRIL 1992 NUMBER 1 ANAL

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