of H3 loop - Accelrys
of H3 loop - Accelrys
of H3 loop - Accelrys
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24<br />
Conclusion<br />
• Rules based recognition <strong>of</strong> hyper-variable <strong>loop</strong> regions can be used to<br />
quickly annotate and properly align sequences for template based<br />
modeling<br />
• Template based methods can model hyper-variable <strong>loop</strong> regions with good<br />
accuracy<br />
• De novo <strong>loop</strong> refinement methods are not bound by template bias and<br />
also show a high degree <strong>of</strong> success for rebuilding the highly flexible<br />
hyper-variable <strong>loop</strong>s such as the <strong>H3</strong> <strong>loop</strong> <strong>of</strong> the 2aab antibody fragment<br />
• Success in our de novo <strong>loop</strong> reconstruction calculation was directly<br />
correlated with the proper positioning <strong>of</strong> the neighboring side chains<br />
• Two methods represent the full solution for Antibody <strong>loop</strong> modeling
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