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Seton Hall Magazine, Winter 2000 - Seton Hall University

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Around the turn of the century,<br />

scientists proposed a radical<br />

approach for controlling infectious<br />

diseases: identify chemical substances<br />

that can go into the human body and kill<br />

pathogenic microorganisms. Thus began<br />

the “age of magic bullets.” Over the past<br />

90 years, the concept led to major<br />

advances in modern medicine, as “magic<br />

bullets” were designed to treat a variety<br />

of infectious diseases. The malicious<br />

disease-causing microbes could now be<br />

held in check. The result: unparalleled<br />

opportunities for treating and preventing<br />

human sickness, along with some<br />

important lessons.<br />

For example, after World War II, the<br />

World Health Organization planned for<br />

the complete eradication of infectious<br />

diseases, such as malaria, through widespread<br />

use of drugs. It was very close<br />

to realizing this daring dream when<br />

disturbing reports started to trickle in.<br />

Patients were not responding to drug<br />

treatment in the usual manner. The<br />

malarial parasites that would normally<br />

be killed by the drug were now somehow<br />

able to “resist” its action, a phenomenon<br />

known as drug resistance.<br />

Today, drug-resistant parasites have<br />

spread so much that famous antimalaria<br />

drugs like chloroquine are no<br />

longer effective in most parts of the<br />

world. So much ground has been lost<br />

that currently 200-300 million individuals<br />

are infected with malaria.<br />

The same story holds true for many<br />

other diseases. Bacteria, parasites and<br />

viruses alike have become drug resistant.<br />

Penicillin, whose discovery in 1928 by<br />

Alexander Fleming revolutionized the<br />

treatment of bacterial infections, is no<br />

longer as effective due to penicillinresistant<br />

bacteria. Treatment of HIVinfected<br />

individuals has become more<br />

problematic due to resistance to the<br />

few available anti-viral drugs. Doctors<br />

are now very careful when prescribing<br />

antibiotics, in hopes of minimizing<br />

the spread of drug-resistant microbes.<br />

Lessons from the Age of Magic Bullets<br />

BY JASON WOODEN ’89, PH.D.<br />

The real fear is that common infections,<br />

which have in the past been<br />

treatable, will now result in patient<br />

death due to impotent “magic bullets.”<br />

There is some good news: Scientists<br />

around the world have stepped up<br />

efforts to identify new drugs and devise<br />

better strategies for outsmarting the<br />

microbes. New life is being given to the<br />

age of “magic bullets.” However, as we<br />

devise bigger and better drugs, we can’t<br />

help but wonder whether the microbes<br />

will outsmart us again. Is there a lesson<br />

in all of this? Does our experience with<br />

drug resistance suggest that nature will<br />

always be greater than our understanding<br />

of it? Does this mean that science is<br />

ultimately fated to concede future battles<br />

such as drug resistance to nature?<br />

In the 21st century, we will see<br />

unequaled advances in many fields of<br />

S c i e n c e<br />

science, wondrous innovations as we<br />

expand the frontiers of knowledge. Will<br />

the frontiers of wisdom also be expanded?<br />

Will we remember the many lessons<br />

nature has already taught us throughout<br />

human history? The age of “magic bullets”<br />

and the subsequent battle against<br />

drug resistance have been lessons in<br />

humility. We can only guess as to what<br />

new lessons await us and how well we<br />

will survive the instruction.<br />

Jason Wooden ’89,<br />

Ph.D., is a staff<br />

scientist at<br />

Procter & Gamble<br />

in Cincinnati, Ohio.<br />

“The real fear is that common<br />

infections, which have in the<br />

past been treatable, will now<br />

result in patient death due to<br />

impotent ‘magic bullets.’ ”<br />

WINTER <strong>2000</strong> 17

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