Workshop: skin barrier treatments
Workshop: skin barrier treatments
Workshop: skin barrier treatments
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Psoriasis, seborrhoea, ichthyosis<br />
Alphosyl lotion Allantoin<br />
Coal tar<br />
Scale reduction<br />
Calmurid Urea<br />
Lactic acid<br />
Dry, hyperkeratosis<br />
Dermadrate Urea<br />
Lactic acid<br />
Dry, hyperkeratosis<br />
Egoderm ointment Ichthammol (Ammonium<br />
bituminosulfonate)<br />
Zinc oxide<br />
Petrolatum<br />
Dry fissured <strong>skin</strong><br />
Hamilton dry <strong>skin</strong> treatment Urea<br />
Petrolatum<br />
Dry <strong>skin</strong><br />
Nutraplus Urea Dry, hyperkeratosis<br />
Urecare / Urederm Urea Dry, hyperkeratosis<br />
Soap<br />
Made by reacting fats with sodium hydroxide (lye), which produces a strongly alkaline product. Washing with soap<br />
disturbs <strong>barrier</strong> function by extracting lipids, increasing TEWL and pH. May be particularly important given that dogs<br />
already have more neutral <strong>skin</strong> pH than humans.<br />
Actives and actions<br />
Lanolin Stable emulsion of water and wool wax (esters, fatty acids and high mole’ wt<br />
alcohol)<br />
Absorbed into <strong>skin</strong>, softens it and prevents drying<br />
Can be used as a carrier to deliver drugs SQ<br />
Petrolatum<br />
Paraffin<br />
Glycerin<br />
Propylene glycol<br />
Urea<br />
Lactic acid<br />
Colloidal oatmeal<br />
Allantoin<br />
Condensation<br />
products<br />
Imidazolidinyl urea<br />
Diazolidinyl urea<br />
Ichthammol<br />
(Ammonium<br />
bituminosulfonate)<br />
Also acts as occlusive agent<br />
Occlusive agents.<br />
Forms hydrophobic layer on <strong>skin</strong> surface (but petrolatum may penetrate into<br />
superficial SC) which traps water in epidermis below<br />
Humectants/hygroscopic agents<br />
Draw water from deeper dermis into St. corneum<br />
May have some keratolytic effect by increasing desquamation, due to<br />
improved St. C hydration<br />
Sulphonated shale oil. It has anti-inflammatory, bactericidal and fungicidal<br />
properties.<br />
Zinc oxide Calamine (ZnO mixed with 1% iron oxide)<br />
Used for insect bite, rash from contact irritants, but no firm evidence exists to<br />
support claims<br />
Whilst there are a large number of available products there is a lot of direct duplication (i.e. different products share the<br />
same active ingredient list) and the actions of all of the actives can really be divided into 2 broad classes: Occlusive agents<br />
and Humectants (hygroscopic agents)<br />
Despite the extensive range available there is no need to stock more than one example of a particular active ingredient<br />
combination. In our practice we commonly use the following for topical use at changing / improving <strong>barrier</strong> function:<br />
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