Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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Statistical Analysis • UTI ▫ Time to event analysis ▫ Log rank test • Other outcomes ▫ Chisquare test
Statistical Analysis • Cox proportionalhazards regression ▫ The effect of a treatment under study has a multiplicative effect on the subject's hazard rate. ▫ Unadjusted hazard ratio ▫ Adjust for significant stratify<strong>in</strong>g variables ▫ Effect modification <strong>in</strong> secondary analyses • KaplanMeier ▫ Estimates of children with UTIs • Number needed to treat
Page 1 and 2: Antibiotic Prophylaxis and Recurren
Page 3 and 4: Outline • Introduction • Method
Page 5 and 6: Sample of articles in past on ppx:
Page 8 and 9: • Essentially, there are no RCT r
Page 10 and 11: Methods • Four centers in Austral
Page 12 and 13: Inclusion Criteria • Children who
Page 14 and 15: Patient enrollment
Page 16 and 17: Imaging • Not required, performed
Page 18 and 19: Adherence • Assessed at 3 month i
Page 20 and 21: Primary and Secondary outcomes •
Page 24 and 25: Statistical Analysis • Cox model
Page 26: Patient Characteristics
Page 29 and 30: Time to symptomatic UTI for all pat
Page 31 and 32: Effect of antibiotics on risk for s
Page 33 and 34: Time to symptomatic UTI
Page 35 and 36: Discussion • The benefit of thera
Page 37 and 38: Recent changes • Five randomized,
Page 39 and 40: Limitations • Study not powered t
Page 41 and 42: Conclusions • Long term, lowdos

Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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