Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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Previous Data • Limited data from previous randomized, controlled trials. ▫ Four trials tended to favor prophylaxis ▫ 171 children in all four studies ▫ 32 children with reflux • Accepted as standard of care for 20 years
Recent changes • Five randomized, controlled trials in children with and without reflux ▫ Showed no benefit of prophylactic antibiotics ▫ None placebo controlled or assessed adherence ▫ Underpowered with 100218 patients • Different results ▫ Lack of adherence, lack of power, unbalanced co interventions.
Page 1 and 2: Antibiotic Prophylaxis and Recurren
Page 3 and 4: Outline • Introduction • Method
Page 5 and 6: Sample of articles in past on ppx:
Page 8 and 9: • Essentially, there are no RCT r
Page 10 and 11: Methods • Four centers in Austral
Page 12 and 13: Inclusion Criteria • Children who
Page 14 and 15: Patient enrollment
Page 16 and 17: Imaging • Not required, performed
Page 18 and 19: Adherence • Assessed at 3 month i
Page 20 and 21: Primary and Secondary outcomes •
Page 22 and 23: Statistical Analysis • UTI ▫ Ti
Page 24 and 25: Statistical Analysis • Cox model
Page 26: Patient Characteristics
Page 29 and 30: Time to symptomatic UTI for all pat
Page 31 and 32: Effect of antibiotics on risk for s
Page 33 and 34: Time to symptomatic UTI
Page 35: Discussion • The benefit of thera
Page 39 and 40: Limitations • Study not powered t
Page 41 and 42: Conclusions • Long term, lowdos

Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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