Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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Primary Outcome • UTI diagnosed in 36 (13%) vs 55 (19%) patients in treatment vs placebo groups (P=0.02) • Hazard Ratio 0.61 (0.40.93) in antibiotic grp • Number Needed to Treat is 14 • Abx group favored across age, sex, reflux status, # of previous UTI, or h/o abx resistance • EXCEPTION – h/o UTI caused by organism resistant to TMPSMX
Effect of antibiotics on risk for symptomatic UTI
Page 1 and 2: Antibiotic Prophylaxis and Recurren
Page 3 and 4: Outline • Introduction • Method
Page 5 and 6: Sample of articles in past on ppx:
Page 8 and 9: • Essentially, there are no RCT r
Page 10 and 11: Methods • Four centers in Austral
Page 12 and 13: Inclusion Criteria • Children who
Page 14 and 15: Patient enrollment
Page 16 and 17: Imaging • Not required, performed
Page 18 and 19: Adherence • Assessed at 3 month i
Page 20 and 21: Primary and Secondary outcomes •
Page 22 and 23: Statistical Analysis • UTI ▫ Ti
Page 24 and 25: Statistical Analysis • Cox model
Page 26: Patient Characteristics
Page 29: Time to symptomatic UTI for all pat
Page 33 and 34: Time to symptomatic UTI
Page 35 and 36: Discussion • The benefit of thera
Page 37 and 38: Recent changes • Five randomized,
Page 39 and 40: Limitations • Study not powered t
Page 41 and 42: Conclusions • Long term, lowdos

Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children

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