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COMPRESSED TABLETS - staging.files.cms.plus.com

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<strong>COMPRESSED</strong> <strong>TABLETS</strong><br />

NCA Resident Course<br />

Walter Vink<br />

Vink Associates<br />

Resident Course in Confectionery Technology


FUNCTION OF INGREDIENTS<br />

CATAGORIES OF INGREDIENTS<br />

Vehicle /Base<br />

Binders<br />

Lubricants<br />

Disintegrants<br />

Flavors and colors<br />

Acidulants


TABLETING VEHICLES / BASES<br />

BASIS FOR SELECTION<br />

Tableting Characteristics<br />

Capacity<br />

Cost


TABLETING VEHICLES / BASES<br />

Most <strong>com</strong>mon materials<br />

Sugar<br />

Dextrose<br />

Sorbitol


BINDERS<br />

FUNCTION<br />

Hold the granule together<br />

Does not hold the table together !!!


BINDERS<br />

TYPICAL MATERIALS<br />

Corn syrup<br />

Gelatin<br />

Gums


Glidant<br />

LUBRICANTS<br />

FUNCTION<br />

Anti-adhesive<br />

Lubricant


LUBRICANTS<br />

Typical materials<br />

Magnesium Stearate<br />

Calcium Stearate<br />

Stearic acid<br />

Amino Acids<br />

Vegetable oil sterines


Wet Dry Direct<br />

Granulation Granulation Compaction<br />

Pulverizing Pulverizing Mixing<br />

Wet Mixing Mixing Tableting<br />

Granulation


WET GRANULATION<br />

Pulverizing<br />

Wet mixing


DRY GRANULATION<br />

Pulverizing<br />

Mixing


DIRECT COMPACTION<br />

Flavor<br />

Dry color<br />

Mixing

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