Coussens CV 11-10 - Departments of Pathology and Laboratory ...
Coussens CV 11-10 - Departments of Pathology and Laboratory ...
Coussens CV 11-10 - Departments of Pathology and Laboratory ...
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30<br />
Lisa M. <strong>Coussens</strong>, Ph.D.<br />
DAMD17-02-1-0693 (PI: Sloane, B; Wayne State University) 08/01/02-07/31/06<br />
Source: Department <strong>of</strong> Defense $5,746,832 directs/yr 1-4<br />
Breast Cancer Center <strong>of</strong> Excellence $49,576 directs/yr 1<br />
Title: Validation <strong>of</strong> Proteases as Therapeutic Targets in Breast Cancer Functional Imaging <strong>of</strong><br />
Protease Expression, Activity <strong>and</strong> Inhibition<br />
Role: Subcontract Principal Investigator $198,307 directs/yr 1-4<br />
The goal <strong>of</strong> this program is to validate proteases as therapeutic targets in breast cancer by<br />
functional imaging <strong>of</strong> protease expression, activity <strong>and</strong> inhibition.<br />
R01 CA94168 (PI: <strong>Coussens</strong>, LM: UCSF) 04/01/02-06/31/07<br />
Source: NIH/NCI $222,500 directs/yr 1<br />
Title: Regulation <strong>of</strong> Epithelial Cancer by MMP-9/gelatinase B $1,<strong>11</strong>2,500 directs/yr 1-5<br />
Role: Principal Investigator<br />
The goal <strong>of</strong> this project is to identify molecules that mediate proliferative <strong>and</strong> cellular pathways<br />
activated by MMP-9.<br />
U54 RR020843 (PI: Smith, J; Burnham Institute) 09/30/04-07/31/06<br />
Source: NIH/National Center for Research Resources $1,916,878 directs/yr<br />
1-5<br />
Title: Center on Proteolytic Pathways<br />
Role: Principal Investigator (Driving Biological Problem #1) $67,306 directs/yr<br />
DBP#1 Proteolytic Pathways in Acute Vascular Response<br />
P01 CA72006 (PI: Werb, Z; UCSF) 07/07/03 – 06/30/08<br />
Source: NIH/NCI $1,523,691 directs/yr 6<br />
Title: Proteases in Cancer Biology <strong>and</strong> Drug Development $6,354,685 directs/yr 6-<br />
<strong>11</strong><br />
Project 3 - Proteases in Models <strong>of</strong> Tumor Initiation/Progression $229,788 directs/yr 6<br />
Role: Co-Investigator, Project 3 $1,172,879 directs/yr 6-<br />
<strong>11</strong><br />
The major goal <strong>of</strong> this project is to study the role <strong>of</strong> proteases in cancer biology.<br />
Core C - Transgenic Animal Models $151,612 directs/yr 6<br />
Role: Director $765,974 directs/yr 6-<br />
<strong>11</strong><br />
The major goal <strong>of</strong> this Core is to develop <strong>and</strong> provide protease null <strong>and</strong> transgenic mice to<br />
program projects.<br />
R01 CA98075 (PI: <strong>Coussens</strong>, LM; UCSF) 07/01/03-06/30/09<br />
Source: NIH/NCI $222,500 directs/yr 1<br />
Title: Microenvironmental Regulation <strong>of</strong> Tumor Progression<br />
$1,<strong>11</strong>2,500 directs/yr 1-<br />
Role: Principal Investigator<br />
5<br />
The overall goal <strong>of</strong> this grant is to determine the role <strong>of</strong> collagen metabolism on epithelial<br />
carcinogenesis.
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