identification of neuroprotective genes against alpha - acumen - The ...

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R02D3.4 Uncharacterized protein C12orf11 R02D3.5 FNTA R02E12.4 Tektin-1 R02F11.4 LRRIQ2 R03G5.1 Elongation factor 1-alpha 2 R03G5.2 MAP2K6 R04A9.2 Eukaryotic translation initiation factor 2C, 1 R05D11.6 Similar to RIKEN cDNA A430101B06 gene R05D3.1 Isoform Beta-1 of DNA topoisomerase 2-beta R05D3.4 E3 ubiquitin-protein ligase BRE1A R06C7.2 Translation initiation factor 2C R06F6.2 Vacuolar protein sorting-associated protein 11 R07B7.16 Orphan nuclear receptor NR5A2 R07E3.1 Cathepsin F precursor R07E4.1 ANKFN1 R07E5.1 GPATCH1 R07G3.3 Nucleoprotein TPR R07H5.2 Carnitine O-palmitoyltransferase 2 R07H5.3 Uncharacterized protein C3orf60 R09B3.4 NEDD8-conjugating enzyme UBE2F R09F10.1 Cathepsin F precursor R10A10.2 RING-box protein 2 R10D12.14 Grb10- interacting GYF protein 2 R10E11.2 ATP6V0C R10E11.3 Ubiquitin carboxyl-terminal hydrolase 46 R10E11.8 ATP6V0C R11A5.1 AP-3 complex subunit beta-2 R12E2.13 Stromal cell-derived factor 2 precursor R12E2.3 PSMD7 R12G8.1 Protein kinase C, eta R12H7.2 Cathepsin D precursor R13D7.7 Glutathione S-transferase pi R151.6 Derlin-2 R151.7 TRAP1 R166.2 Cleft lip and palate transmembrane protein 1 R186.3 SRPR protein, beta subunit R74.3 X-box binding protein 1 80
R74.4 DNAJB1 precursor T01B7.4 Peptidyl-prolyl cis-trans isomerase H T01C3.3 E3 ubiquitin-protein ligase RNF8 T01C8.1 PRKAA2 T01D1.1 Heme oxygenase 2 T01D3.3 IgGFc-binding protein precursor T01G1.1 Kinesin family member 21B T01G5.7 E3 ubiquitin-protein ligase RNF8 T01G6.1 DHRS4 T01H3.2 DKFZP434B0335 protein T02C1.1 Tripartite motif-containing protein 5 T03E6.7 Cathepsin L precursor T03F1.1 UBE1L T03F6.2 DNAJA5 T03G11.4 MAN1B1 T03G11.6 Methyltransferase like 9 isoform 1 T04A8.16 Calpain-7 T04A8.7 1,4-alpha-glucan branching enzyme T04A8.9 DnaJ homolog subfamily B member 7 T04C9.4 Cysteine and glycine-rich protein 2 T04G9.3 VIP36 precursor T04H1.9 Tubulin beta-2C chain T05A12.4 SNF2 histone linker PHD RING helicase T05C12.7 T-complex protein 1, alpha subunit T05C3.5 DnaJ homolog subfamily A member 2 T05D4.1 Fructose-bisphosphate aldolase A T05E11.3 Endoplasmin precursor T05E11.5 Minor histocompatibility antigen H13 T05E11.6 GPI-anchor transamidase precursor T05H10.1 Ubiquitin carboxyl-terminal hydrolase 47 T05H10.5 Isoform 2 of Ubiquitin conjugation factor E4 B T05H4.4 NADH-cytochrome b5 reductase T06C10.3 Proto-oncogene c-fes variant 3 T06D8.8 HSPC027 T06E8.1 AGPAT2 T06G6.4 Centromere protein F T07F12.4 Serine/threonine-protein kinase ULK2 81
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IDENTIFICATION OF NEUROPROTECTIVE G
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ABSTRACT Recent functional analyses
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E3 Ubiquitin ligase ER Endoplasmic
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RT-PCR Reverse transcriptase polyme
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TAG-278 Temporary assigned gene 278
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p38 Mitogen-activated protein kinas
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ACKNOWLEDGMENTS First and foremost,
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CONTENTS ABSTRACT .................
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a. Abstract .......................
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LIST OF FIGURES 1.1. Schematic repr
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Parkinson disease CHAPTER ONE INTRO
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al., 2006) and torsinA (Cao et al.,
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endoplasmic reticulum (ER) to Golgi
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c-Jun N-terminal kinase and caspase
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lysosomal protease promotes α-syn
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ROS, which may oxidize DA (a neurot
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together, although anti-oxidant act
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multicellular eukaryotic model orga
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C. elegans PD models C. elegans off
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Current studies To investigate gene
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Specific outcomes and future direct
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Corti, O., Hampe, C., Koutnikova, H
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Lautier, C., Goldwurm, S., Dürr, A
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Scherzer, C.R., Jensen, R.V., Gulla
Page 49 and 50: Willcox, B.J., Donlon, T.A., He, Q.
Page 51 and 52: Table 1.2. Summary of selected inve
Page 53 and 54: FIGURE LEGENDS Fig. 1.1. Schematic
Page 55 and 56: ABSTRACT Genomic multiplication of
Page 57 and 58: et al., 2003). Maintenance of DA ne
Page 59 and 60: Pdat-1::FLAG-R05D11.6, Punc-54::DsR
Page 61 and 62: Biochemicals) and 1:10000 horseradi
Page 63 and 64: was washed with 100 µl RNase-free
Page 65 and 66: and effectively discerned via RNAi
Page 67 and 68: protein. The primary RNAi screen of
Page 69 and 70: expressing a polyglutamine::GFP fus
Page 71 and 72: stage (Fig. 2.2B-D). Two genes exhi
Page 73 and 74: with strong expression localized to
Page 75 and 76: Our data demonstrating that the C.
Page 77 and 78: disparate datasets, such as those o
Page 79 and 80: Driscoll, M., Gerstbrein, B. (2003)
Page 81 and 82: Singleton, A.B., Farrer, M., Johnso
Page 83 and 84: Table 2.2. Bioinformatic associatio
Page 85 and 86: Table 2.4. Results of all genes kno
Page 87 and 88: C09G12.9 Tumor susceptibility gene
Page 89 and 90: C32B5.13 Cathepsin H precursor C32B
Page 91 and 92: D1014.3 Alpha-soluble NSF attachmen
Page 93 and 94: F22B7.5 DNAJA3, mitochondrial precu
Page 95 and 96: F40F4.5 Tubulin alpha-ubiquitous ch
Page 97 and 98: F54F7.5 Serine/threonine kinase 24
Page 99: K07A9.2 CAMK1 K07C11.9 Hypothetical
Page 103 and 104: T22D1.9 PSMD2 T22F3.2 Ubiquitin spe
Page 105 and 106: Y38F2AL.3 Vacuolar ATP synthase sub
Page 107 and 108: Y73C8C.8 CENPE variant protein (Fra
Page 109 and 110: Table 2.5. Summary of RNAi knockdow
Page 111 and 112: Figure 2.2 91
Page 117 and 118: FIGURE LEGENDS Figure 2.1. RNAi kno
Page 119 and 120: came from genes that were co-expres
Page 121 and 122: ABSTRACT Multiple Parkinson disease
Page 123 and 124: vacuoles (mammalian equivalent of l
Page 125 and 126: neuroprotection when the animals we
Page 127 and 128: To investigate the genetic interact
Page 129 and 130: illustrated that α-syn overexpress
Page 131 and 132: main contributor of α-syn phosphor
Page 133 and 134: Hoozemans, J.J., van Haastert, E.S.
Page 137 and 138: FIGURE LEGENDS Figure 3.1. RAB3A, R
Page 139 and 140: CHAPTER FOUR RNA INTERFERENCE SCREE
Page 141 and 142: INTRODUCTION Central to Parkinson d
Page 143 and 144: thermotolerance (Lithgow et al., 19
Page 145 and 146: mCherry were transferred onto NGM p
Page 147 and 148: 20°C for 72 hrs. The gravid adults
Page 149 and 150: pathways downstream of DAF-2 exclud
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were assayed by growing the RNAi-tr
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while DOG treatment enhanced α-syn
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enhance α-syn misfolding in a daf-
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REFERENCES Bar-On, P., Crews, L., K
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Lesage, S., Brice, A. (2009) Hum Mo
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Table 4.1. Summary of genes analyze
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C12D12.2 Excitatory amino acid tran
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C47B2.2 n/a C47C12.6 Amiloride-sens
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F18A1.5 Replication protein A F18E3
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F46E10.10 Malate dehydrogenase F46E
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K08H10.1 Dentin sialophosphoprotein
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T05A10.5 Cysteine-rich secretory pr
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W03G9.6 Platelet-activating factor
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Y58G8A.1 Acetylcholine receptor sub
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Table 4.2. Summary of positive gene
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Figure 4.1 161
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Figure 4.3 163
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Figure 4.5 165
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Figure 4.7 167
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Figure 4.4. Graph illustrating the
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in yeast but not in humans. In yeas
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kinase that has also been shown to
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mir-2/mir-43/mir-250/mir-797 superf
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of djr-1.1 and djr-1.2 enhance α-s
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expensive, since they require high
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Ambros, V. (2001) Cell 107, 823-826
Page 203 and 204:
Yi, J., Tang, X.M. (1999) Cell Res
Page 205 and 206:
Figure 5.2 185
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