identification of neuroprotective genes against alpha - acumen - The ...

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Page 1 and 2: IDENTIFICATION OF NEUROPROTECTIVE G
Page 3 and 4: ABSTRACT Recent functional analyses
Page 5 and 6: E3 Ubiquitin ligase ER Endoplasmic
Page 7 and 8: RT-PCR Reverse transcriptase polyme
Page 9 and 10: TAG-278 Temporary assigned gene 278
Page 11 and 12: p38 Mitogen-activated protein kinas
Page 13 and 14: ACKNOWLEDGMENTS First and foremost,
Page 15 and 16: CONTENTS ABSTRACT .................
Page 17 and 18: a. Abstract .......................
Page 19 and 20: LIST OF FIGURES 1.1. Schematic repr
Page 21 and 22: Parkinson disease CHAPTER ONE INTRO
Page 23 and 24: al., 2006) and torsinA (Cao et al.,
Page 25 and 26: endoplasmic reticulum (ER) to Golgi
Page 27 and 28: c-Jun N-terminal kinase and caspase
Page 29 and 30: lysosomal protease promotes α-syn
Page 31 and 32: ROS, which may oxidize DA (a neurot
Page 33 and 34: together, although anti-oxidant act
Page 35 and 36: multicellular eukaryotic model orga
Page 37 and 38: C. elegans PD models C. elegans off
Page 39 and 40: Current studies To investigate gene
Page 41: Specific outcomes and future direct
Page 45 and 46: Lautier, C., Goldwurm, S., Dürr, A
Page 47 and 48: Scherzer, C.R., Jensen, R.V., Gulla
Page 49 and 50: Willcox, B.J., Donlon, T.A., He, Q.
Page 51 and 52: Table 1.2. Summary of selected inve
Page 53 and 54: FIGURE LEGENDS Fig. 1.1. Schematic
Page 55 and 56: ABSTRACT Genomic multiplication of
Page 57 and 58: et al., 2003). Maintenance of DA ne
Page 59 and 60: Pdat-1::FLAG-R05D11.6, Punc-54::DsR
Page 61 and 62: Biochemicals) and 1:10000 horseradi
Page 63 and 64: was washed with 100 µl RNase-free
Page 65 and 66: and effectively discerned via RNAi
Page 67 and 68: protein. The primary RNAi screen of
Page 69 and 70: expressing a polyglutamine::GFP fus
Page 71 and 72: stage (Fig. 2.2B-D). Two genes exhi
Page 73 and 74: with strong expression localized to
Page 75 and 76: Our data demonstrating that the C.
Page 77 and 78: disparate datasets, such as those o
Page 79 and 80: Driscoll, M., Gerstbrein, B. (2003)
Page 81 and 82: Singleton, A.B., Farrer, M., Johnso
Page 83 and 84: Table 2.2. Bioinformatic associatio
Page 85 and 86: Table 2.4. Results of all genes kno
Page 87 and 88: C09G12.9 Tumor susceptibility gene
Page 89 and 90: C32B5.13 Cathepsin H precursor C32B
Page 91 and 92: D1014.3 Alpha-soluble NSF attachmen
Page 93 and 94:
F22B7.5 DNAJA3, mitochondrial precu
Page 95 and 96:
F40F4.5 Tubulin alpha-ubiquitous ch
Page 97 and 98:
F54F7.5 Serine/threonine kinase 24
Page 99 and 100:
K07A9.2 CAMK1 K07C11.9 Hypothetical
Page 101 and 102:
R74.4 DNAJB1 precursor T01B7.4 Pept
Page 103 and 104:
T22D1.9 PSMD2 T22F3.2 Ubiquitin spe
Page 105 and 106:
Y38F2AL.3 Vacuolar ATP synthase sub
Page 107 and 108:
Y73C8C.8 CENPE variant protein (Fra
Page 109 and 110:
Table 2.5. Summary of RNAi knockdow
Page 111 and 112:
Figure 2.2 91
Page 113 and 114:
Figure 2.4 93
Page 115 and 116:
Figure 2.6 95
Page 117 and 118:
FIGURE LEGENDS Figure 2.1. RNAi kno
Page 119 and 120:
came from genes that were co-expres
Page 121 and 122:
ABSTRACT Multiple Parkinson disease
Page 123 and 124:
vacuoles (mammalian equivalent of l
Page 125 and 126:
neuroprotection when the animals we
Page 127 and 128:
To investigate the genetic interact
Page 129 and 130:
illustrated that α-syn overexpress
Page 131 and 132:
main contributor of α-syn phosphor
Page 133 and 134:
Hoozemans, J.J., van Haastert, E.S.
Page 135 and 136:
Figure 3.2 115
Page 137 and 138:
FIGURE LEGENDS Figure 3.1. RAB3A, R
Page 139 and 140:
CHAPTER FOUR RNA INTERFERENCE SCREE
Page 141 and 142:
INTRODUCTION Central to Parkinson d
Page 143 and 144:
thermotolerance (Lithgow et al., 19
Page 145 and 146:
mCherry were transferred onto NGM p
Page 147 and 148:
20°C for 72 hrs. The gravid adults
Page 149 and 150:
pathways downstream of DAF-2 exclud
Page 151 and 152:
were assayed by growing the RNAi-tr
Page 153 and 154:
while DOG treatment enhanced α-syn
Page 155 and 156:
enhance α-syn misfolding in a daf-
Page 157 and 158:
REFERENCES Bar-On, P., Crews, L., K
Page 159 and 160:
Lesage, S., Brice, A. (2009) Hum Mo
Page 161 and 162:
Table 4.1. Summary of genes analyze
Page 163 and 164:
C12D12.2 Excitatory amino acid tran
Page 165 and 166:
C47B2.2 n/a C47C12.6 Amiloride-sens
Page 167 and 168:
F18A1.5 Replication protein A F18E3
Page 169 and 170:
F46E10.10 Malate dehydrogenase F46E
Page 171 and 172:
K08H10.1 Dentin sialophosphoprotein
Page 173 and 174:
T05A10.5 Cysteine-rich secretory pr
Page 175 and 176:
W03G9.6 Platelet-activating factor
Page 177 and 178:
Y58G8A.1 Acetylcholine receptor sub
Page 179 and 180:
Table 4.2. Summary of positive gene
Page 181 and 182:
Figure 4.1 161
Page 183 and 184:
Figure 4.3 163
Page 185 and 186:
Figure 4.5 165
Page 187 and 188:
Figure 4.7 167
Page 189 and 190:
Figure 4.4. Graph illustrating the
Page 191 and 192:
in yeast but not in humans. In yeas
Page 193 and 194:
kinase that has also been shown to
Page 195 and 196:
mir-2/mir-43/mir-250/mir-797 superf
Page 197 and 198:
of djr-1.1 and djr-1.2 enhance α-s
Page 199 and 200:
expensive, since they require high
Page 201 and 202:
Ambros, V. (2001) Cell 107, 823-826
Page 203 and 204:
Yi, J., Tang, X.M. (1999) Cell Res
Page 205 and 206:
Figure 5.2 185
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