Selenium - The Risk Assessment Information System

Dose (mg Se/kg bw/day)
1000.00
100.00
10.00
1.00
0.10
0.01
78
70 74
86
69 72
82
76 82 82 76 82 81 76
72 67 70 66 72
77 71 66
67 70 67 70
75 66
66 66 77
68
80
70
78
69
72
86
82 76
82
82
76
71 75
70
77
76 70
82727072
81
69
74
80
75 70 72
69 74
71 69 70 75 74 69 74 70 71 69 68 75 69 70 69 70 69 70
71
66
69
70
69
74
74 71
74
74
89
80
89 80 74 72 85 85 72 85 69 72
85 70 75 72 74 86 70 75
70 80
89 70
88 74 80
73
89
80
89
72 80 89
85 8575
74 8675
85 85
80
8085
Wildlife TRV Derivation Process Data Evaluation Score
80
80 67
8873 80 73
71 74 69 74 77 68 73
69 72
68
69
72
77
74 69
78
69
69
77 74
74
Figure 6.1 Mammalian TRV Derivation for Selenium
79 78
80
70 73
70 80 70
67
70
79 78
80
80
73
78
Lowest-Observed Adverse Effect Dose
Paired values from same study when joined by line
No-Observed Adverse Effect Dose
1) There are at least three results available for two test species within the growth, reproduction, and mortality effect groups.
There are enough data to derive a TRV.
2) There are three NOAEL results available within the growth and reproduction effect groups for calculation of a geometric mean.
82
82
81
81
78 73
78 73
80
74
80 89 82
89
74 85 83 73 85 68 85 73 84
78 83
79 70 72
68 80 86 73 78 74 77
88
69
78 68 86
72 80
68
82
85
74
85
83
89
80
89
85 78
83 78
80 86
73
84
79
7488
8878
86
73 74
79
77
83 74 74 68 73 73 77
78 77 69 72
68 67
72 80 74 72 73 78 72 66 72 78 73 73
72
69 73 68
67
3) The geometric mean is equal to 0.437 mg selenium/kg bw/d. However, this value is higher than the lowest bounded LOAEL for results within the reproduction, growth, and survival (MOR) effect groups.
4) The mammalian wildlife TRV for selenium is equal to 0.143 mg selenium/kg bw/day which is the highest NOAEL value lower than the lowest LOAEL value for reproduction and growth.
78
80 86 95
70
74
71
92 77
69
78
85
86
78
87 86
90
7887
92
80 86 95
73
79
89
79
73 79
86
73
81 86
Geometric Mean of NOAELs
for reproduction and growth =
0.437
86 77 67
78
81 84
84 89 76 89 77 83 89 68 79 76 89 74 78 77 68 82 88 82 89 74 79 77 82 74 84 73 68 70
84 79 77 93 69 84 76 83 78 84 93 68 77 74 83 82 78 77 74 78 77
92 68 82 90 73 93 78 84
67 82 72 77 77
84
71
90 85
84
85 84
86
84 89
84
84
89
89
83
89
89 82 88
84
79
828479
89
93
85
77
77908482
82
78 9293
78
8478
84 93
82 77 82
837783
77 77
82 78 77
81 77 82 72 78 78 72 71 82 81 78 82 81 72 76 72 82 72 76 73 77 81 72 76 71 77 73 76 78 73 76 77 78 72 70 76 82 76 82 77 77 77 72
76 73
81 71
81 78
84
85
TRV = Highest bounded NOAEL lower
than lowest bounded LOAEL for
reproduction, growth or survival = 0.143
(Result # 268; Table 6.1)
79
82 84
83 73 68
85
78 79 77 94 83 90
94 78 84 85 91 72 78 85 78 77 78 73 83 85 77 78 74
91 77 73 87
83 85
87 85 86 85
78 88 91
85
77
85
78
97
82
83
84
85
83
94
83
90
94 78 84
85
8578
91
85
91
83 87
7891
85 86
97
83 72
73
73
78
73
82 72
82 79
76
85
Biochemical (BIO) Behavior (BEH) Physiology (PHY)
Pathology (PTH) Reproduction (REP)
Growth (GRO) Mortality (MOR)
BIO-NOAEL BIO-LOAEL BEH-NOAEL BEH-LOAEL PHY-NOAEL PHY-LOAEL PTH-NOAEL PTH-LOAEL REP-NOAEL REP-LOAEL GRO-NOAEL GRO-LOAEL MOR-NOAEL MOR-LOAEL
83
Eco-SSL for Selenium 24 July 2007