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Selenium - The Risk Assessment Information System

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Dose (mg Se/kg bw/day)<br />

1000.00<br />

100.00<br />

10.00<br />

1.00<br />

0.10<br />

0.01<br />

78<br />

70 74<br />

86<br />

69 72<br />

82<br />

76 82 82 76 82 81 76<br />

72 67 70 66 72<br />

77 71 66<br />

67 70 67 70<br />

75 66<br />

66 66 77<br />

68<br />

80<br />

70<br />

78<br />

69<br />

72<br />

86<br />

82 76<br />

82<br />

82<br />

76<br />

71 75<br />

70<br />

77<br />

76 70<br />

82727072<br />

81<br />

69<br />

74<br />

80<br />

75 70 72<br />

69 74<br />

71 69 70 75 74 69 74 70 71 69 68 75 69 70 69 70 69 70<br />

71<br />

66<br />

69<br />

70<br />

69<br />

74<br />

74 71<br />

74<br />

74<br />

89<br />

80<br />

89 80 74 72 85 85 72 85 69 72<br />

85 70 75 72 74 86 70 75<br />

70 80<br />

89 70<br />

88 74 80<br />

73<br />

89<br />

80<br />

89<br />

72 80 89<br />

85 8575<br />

74 8675<br />

85 85<br />

80<br />

8085<br />

Wildlife TRV Derivation Process Data Evaluation Score<br />

80<br />

80 67<br />

8873 80 73<br />

71 74 69 74 77 68 73<br />

69 72<br />

68<br />

69<br />

72<br />

77<br />

74 69<br />

78<br />

69<br />

69<br />

77 74<br />

74<br />

Figure 6.1 Mammalian TRV Derivation for <strong>Selenium</strong><br />

79 78<br />

80<br />

70 73<br />

70 80 70<br />

67<br />

70<br />

79 78<br />

80<br />

80<br />

73<br />

78<br />

Lowest-Observed Adverse Effect Dose<br />

Paired values from same study when joined by line<br />

No-Observed Adverse Effect Dose<br />

1) <strong>The</strong>re are at least three results available for two test species within the growth, reproduction, and mortality effect groups.<br />

<strong>The</strong>re are enough data to derive a TRV.<br />

2) <strong>The</strong>re are three NOAEL results available within the growth and reproduction effect groups for calculation of a geometric mean.<br />

82<br />

82<br />

81<br />

81<br />

78 73<br />

78 73<br />

80<br />

74<br />

80 89 82<br />

89<br />

74 85 83 73 85 68 85 73 84<br />

78 83<br />

79 70 72<br />

68 80 86 73 78 74 77<br />

88<br />

69<br />

78 68 86<br />

72 80<br />

68<br />

82<br />

85<br />

74<br />

85<br />

83<br />

89<br />

80<br />

89<br />

85 78<br />

83 78<br />

80 86<br />

73<br />

84<br />

79<br />

7488<br />

8878<br />

86<br />

73 74<br />

79<br />

77<br />

83 74 74 68 73 73 77<br />

78 77 69 72<br />

68 67<br />

72 80 74 72 73 78 72 66 72 78 73 73<br />

72<br />

69 73 68<br />

67<br />

3) <strong>The</strong> geometric mean is equal to 0.437 mg selenium/kg bw/d. However, this value is higher than the lowest bounded LOAEL for results within the reproduction, growth, and survival (MOR) effect groups.<br />

4) <strong>The</strong> mammalian wildlife TRV for selenium is equal to 0.143 mg selenium/kg bw/day which is the highest NOAEL value lower than the lowest LOAEL value for reproduction and growth.<br />

78<br />

80 86 95<br />

70<br />

74<br />

71<br />

92 77<br />

69<br />

78<br />

85<br />

86<br />

78<br />

87 86<br />

90<br />

7887<br />

92<br />

80 86 95<br />

73<br />

79<br />

89<br />

79<br />

73 79<br />

86<br />

73<br />

81 86<br />

Geometric Mean of NOAELs<br />

for reproduction and growth =<br />

0.437<br />

86 77 67<br />

78<br />

81 84<br />

84 89 76 89 77 83 89 68 79 76 89 74 78 77 68 82 88 82 89 74 79 77 82 74 84 73 68 70<br />

84 79 77 93 69 84 76 83 78 84 93 68 77 74 83 82 78 77 74 78 77<br />

92 68 82 90 73 93 78 84<br />

67 82 72 77 77<br />

84<br />

71<br />

90 85<br />

84<br />

85 84<br />

86<br />

84 89<br />

84<br />

84<br />

89<br />

89<br />

83<br />

89<br />

89 82 88<br />

84<br />

79<br />

828479<br />

89<br />

93<br />

85<br />

77<br />

77908482<br />

82<br />

78 9293<br />

78<br />

8478<br />

84 93<br />

82 77 82<br />

837783<br />

77 77<br />

82 78 77<br />

81 77 82 72 78 78 72 71 82 81 78 82 81 72 76 72 82 72 76 73 77 81 72 76 71 77 73 76 78 73 76 77 78 72 70 76 82 76 82 77 77 77 72<br />

76 73<br />

81 71<br />

81 78<br />

84<br />

85<br />

TRV = Highest bounded NOAEL lower<br />

than lowest bounded LOAEL for<br />

reproduction, growth or survival = 0.143<br />

(Result # 268; Table 6.1)<br />

79<br />

82 84<br />

83 73 68<br />

85<br />

78 79 77 94 83 90<br />

94 78 84 85 91 72 78 85 78 77 78 73 83 85 77 78 74<br />

91 77 73 87<br />

83 85<br />

87 85 86 85<br />

78 88 91<br />

85<br />

77<br />

85<br />

78<br />

97<br />

82<br />

83<br />

84<br />

85<br />

83<br />

94<br />

83<br />

90<br />

94 78 84<br />

85<br />

8578<br />

91<br />

85<br />

91<br />

83 87<br />

7891<br />

85 86<br />

97<br />

83 72<br />

73<br />

73<br />

78<br />

73<br />

82 72<br />

82 79<br />

76<br />

85<br />

Biochemical (BIO) Behavior (BEH) Physiology (PHY)<br />

Pathology (PTH) Reproduction (REP)<br />

Growth (GRO) Mortality (MOR)<br />

BIO-NOAEL BIO-LOAEL BEH-NOAEL BEH-LOAEL PHY-NOAEL PHY-LOAEL PTH-NOAEL PTH-LOAEL REP-NOAEL REP-LOAEL GRO-NOAEL GRO-LOAEL MOR-NOAEL MOR-LOAEL<br />

83<br />

Eco-SSL for <strong>Selenium</strong> 24 July 2007

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