18.08.2013 Views

Selenium - The Risk Assessment Information System

Selenium - The Risk Assessment Information System

Selenium - The Risk Assessment Information System

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

Dose (mg Se/kg bw/day)<br />

1000.00<br />

100.00<br />

10.00<br />

1.00<br />

0.10<br />

0.01<br />

78<br />

70 74<br />

86<br />

69 72<br />

82<br />

76 82 82 76 82 81 76<br />

72 67 70 66 72<br />

77 71 66<br />

67 70 67 70<br />

75 66<br />

66 66 77<br />

68<br />

80<br />

70<br />

78<br />

69<br />

72<br />

86<br />

82 76<br />

82<br />

82<br />

76<br />

71 75<br />

70<br />

77<br />

76 70<br />

82727072<br />

81<br />

69<br />

74<br />

80<br />

75 70 72<br />

69 74<br />

71 69 70 75 74 69 74 70 71 69 68 75 69 70 69 70 69 70<br />

71<br />

66<br />

69<br />

70<br />

69<br />

74<br />

74 71<br />

74<br />

74<br />

89<br />

80<br />

89 80 74 72 85 85 72 85 69 72<br />

85 70 75 72 74 86 70 75<br />

70 80<br />

89 70<br />

88 74 80<br />

73<br />

89<br />

80<br />

89<br />

72 80 89<br />

85 8575<br />

74 8675<br />

85 85<br />

80<br />

8085<br />

Wildlife TRV Derivation Process Data Evaluation Score<br />

80<br />

80 67<br />

8873 80 73<br />

71 74 69 74 77 68 73<br />

69 72<br />

68<br />

69<br />

72<br />

77<br />

74 69<br />

78<br />

69<br />

69<br />

77 74<br />

74<br />

Figure 6.1 Mammalian TRV Derivation for <strong>Selenium</strong><br />

79 78<br />

80<br />

70 73<br />

70 80 70<br />

67<br />

70<br />

79 78<br />

80<br />

80<br />

73<br />

78<br />

Lowest-Observed Adverse Effect Dose<br />

Paired values from same study when joined by line<br />

No-Observed Adverse Effect Dose<br />

1) <strong>The</strong>re are at least three results available for two test species within the growth, reproduction, and mortality effect groups.<br />

<strong>The</strong>re are enough data to derive a TRV.<br />

2) <strong>The</strong>re are three NOAEL results available within the growth and reproduction effect groups for calculation of a geometric mean.<br />

82<br />

82<br />

81<br />

81<br />

78 73<br />

78 73<br />

80<br />

74<br />

80 89 82<br />

89<br />

74 85 83 73 85 68 85 73 84<br />

78 83<br />

79 70 72<br />

68 80 86 73 78 74 77<br />

88<br />

69<br />

78 68 86<br />

72 80<br />

68<br />

82<br />

85<br />

74<br />

85<br />

83<br />

89<br />

80<br />

89<br />

85 78<br />

83 78<br />

80 86<br />

73<br />

84<br />

79<br />

7488<br />

8878<br />

86<br />

73 74<br />

79<br />

77<br />

83 74 74 68 73 73 77<br />

78 77 69 72<br />

68 67<br />

72 80 74 72 73 78 72 66 72 78 73 73<br />

72<br />

69 73 68<br />

67<br />

3) <strong>The</strong> geometric mean is equal to 0.437 mg selenium/kg bw/d. However, this value is higher than the lowest bounded LOAEL for results within the reproduction, growth, and survival (MOR) effect groups.<br />

4) <strong>The</strong> mammalian wildlife TRV for selenium is equal to 0.143 mg selenium/kg bw/day which is the highest NOAEL value lower than the lowest LOAEL value for reproduction and growth.<br />

78<br />

80 86 95<br />

70<br />

74<br />

71<br />

92 77<br />

69<br />

78<br />

85<br />

86<br />

78<br />

87 86<br />

90<br />

7887<br />

92<br />

80 86 95<br />

73<br />

79<br />

89<br />

79<br />

73 79<br />

86<br />

73<br />

81 86<br />

Geometric Mean of NOAELs<br />

for reproduction and growth =<br />

0.437<br />

86 77 67<br />

78<br />

81 84<br />

84 89 76 89 77 83 89 68 79 76 89 74 78 77 68 82 88 82 89 74 79 77 82 74 84 73 68 70<br />

84 79 77 93 69 84 76 83 78 84 93 68 77 74 83 82 78 77 74 78 77<br />

92 68 82 90 73 93 78 84<br />

67 82 72 77 77<br />

84<br />

71<br />

90 85<br />

84<br />

85 84<br />

86<br />

84 89<br />

84<br />

84<br />

89<br />

89<br />

83<br />

89<br />

89 82 88<br />

84<br />

79<br />

828479<br />

89<br />

93<br />

85<br />

77<br />

77908482<br />

82<br />

78 9293<br />

78<br />

8478<br />

84 93<br />

82 77 82<br />

837783<br />

77 77<br />

82 78 77<br />

81 77 82 72 78 78 72 71 82 81 78 82 81 72 76 72 82 72 76 73 77 81 72 76 71 77 73 76 78 73 76 77 78 72 70 76 82 76 82 77 77 77 72<br />

76 73<br />

81 71<br />

81 78<br />

84<br />

85<br />

TRV = Highest bounded NOAEL lower<br />

than lowest bounded LOAEL for<br />

reproduction, growth or survival = 0.143<br />

(Result # 268; Table 6.1)<br />

79<br />

82 84<br />

83 73 68<br />

85<br />

78 79 77 94 83 90<br />

94 78 84 85 91 72 78 85 78 77 78 73 83 85 77 78 74<br />

91 77 73 87<br />

83 85<br />

87 85 86 85<br />

78 88 91<br />

85<br />

77<br />

85<br />

78<br />

97<br />

82<br />

83<br />

84<br />

85<br />

83<br />

94<br />

83<br />

90<br />

94 78 84<br />

85<br />

8578<br />

91<br />

85<br />

91<br />

83 87<br />

7891<br />

85 86<br />

97<br />

83 72<br />

73<br />

73<br />

78<br />

73<br />

82 72<br />

82 79<br />

76<br />

85<br />

Biochemical (BIO) Behavior (BEH) Physiology (PHY)<br />

Pathology (PTH) Reproduction (REP)<br />

Growth (GRO) Mortality (MOR)<br />

BIO-NOAEL BIO-LOAEL BEH-NOAEL BEH-LOAEL PHY-NOAEL PHY-LOAEL PTH-NOAEL PTH-LOAEL REP-NOAEL REP-LOAEL GRO-NOAEL GRO-LOAEL MOR-NOAEL MOR-LOAEL<br />

83<br />

Eco-SSL for <strong>Selenium</strong> 24 July 2007

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!