Regioselective Reductive Cross-Coupling Reaction
Regioselective Reductive Cross-Coupling Reaction
Regioselective Reductive Cross-Coupling Reaction
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Class II<br />
Micalizio et. al. J.Am. Chem. Soc .2006 128, 2764.<br />
Substrate scope is limited based on<br />
factors influencing reactivity and resioselectivity.<br />
R 1<br />
Ti(O i Pr) 4<br />
R 2<br />
-78 ºC to -50 ºC<br />
2 h<br />
i PrMgCl<br />
R 1<br />
R 2<br />
Ti(O i Pr) 2<br />
Sato, F. et. al.<br />
Tetrahedron Lett. 1995, 36, 3203.<br />
Ti(O i Pr) 2<br />
Ti(O i Pr) 2<br />
D 2O<br />
R 1<br />
R 2<br />
D<br />
D<br />
up to 100%<br />
Z :E = >99: 1<br />
the tetherd alkoxide plays a central role<br />
in determing regio selection. Jin Kun Cha et. al. J. Am. Chem. Soc. 1996, 118, 4198. 4/16
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