PD. Dr. Ana Martin-Villalba Department of Molecular ... - HBIGS

PD. Dr. Ana Martin-Villalba
Department of Molecular Neurobiology
German Cancer Research Center
69120 Heidelberg, Germany
Phone: +49-(0)6221-42 3766
Fax: +49-(0)6221-42 3777
E-mail: a.martin-villalba@dkfz.de
13/11/1971, Madrid
CURRICULUM VITAE
July 2006-
March 1999 -
June 2006
Appointed group leader of “Molecular Neurobiology”
Department, German Cancer Research Center, Heidelberg
Group leader at the Division of Immunogenetics (Prof. Dr.
P.H. Krammer), German Cancer Research Center, Heidelberg
March-Apr.1998 Guest-scientist at the laboratory of Prof. R. Testi, University Tor
Jan-Feb.1999 Vergata, Rome, Italy (Vigoni Program)
Jan. 1998 - Postdoctoral fellow, Institute of Physiology and Pathophysio-
Feb. 1999 logy, University of Heidelberg
June-Dec.1997
Aug. 1995-
July 1998
Medical Assistant at the Neurology Department, University of Heidelberg
PhD: Institute of Physiology and Pathophysiophysiology,
University of Heidelberg, Germany
1989 - 1995 Faculty of Medicine, University of Murcia, Spain
1993 Faculty of Medicine, University of Leeds, U.K. (ERASMUS-Program)
Summer 1992
University Hospital for Internal Medicine, Vienna, Austria
HONORS
Walther und Christine Richtzenhain-Award (2006)
Heinz Maier-Leibnitz-Award (2006);
Paul Ehrlich und Ludwig Darmstädter Young investigator Award (2006);
German Academic Exchange Service (DAAD), Bonn, Germany (1997)
FIELDS OF INTEREST
Molecular Neurobiology, Stem cell biology, Brain tumors, Axonal regeneration, the role of
CD95/CD95L-system in the CNS

CURRENTLY FUNDED PROJECTS
BMBF, therapy of spinal cord injuries; BMBF, therapy of Glioblastoma Multiforme; Helmholtz
Allianz on System Biology: Determinants of PI(3) kinase signalling as a response to CD95
stimulation. Teilprojekt Nr. BioRN-INb-07: Role of CD95 in Inflammatory diseases.
PUBLICATIONS (10 most important publications):
Corsini, N., Sancho-Martinez, I., Laudenklos, S., Glagow, D., Kumar, S., Letellier, E., Koch,
P., Teodorczyk, M., Kleber, S., Klussmann, S., Wiestler, B., Brüstle, O., Gieffers, C., Hill, O.,
Thiemann, M., Seedorf, M., Gretz, N., Sprengel, R., Celikel, T., Martin-Villalba, A. (-). The
death receptor CD95 activates adult neural stem cells for working memory formation and
brain repair. Cell Stem Cell, In press
Sancho-Martinez I, and Martin-Villalba,A. (2009). Tyrosine phosphorylation and CD95: a
FAScinating switch. Cell Cycle 8, 838-842.
Kleber S, Sancho-Martinez I, Wiestler B, Beisel A, Gieffers C, Hill O, Thiemann M, Mueller W,
Sykora J, Kuhn A, Schreglmann N, Letellier E, Zuliani C, Klussmann S, Teodorczyk M, Gröne
HJ, Ganten TM, Sültmann H, Tüttenberg J, von Deimling A, Regnier-Vigouroux A, Herold-
Mende C, Martin-Villalba A. (2008). Yes and PI3K bind CD95 to signal invasion of
glioblastoma. Cancer Cell, 13:235-248.
Zuliani C, Kleber S, Klussmann S, Wenger T, Kenzelmann M, Schreglmann N, Martinez A,
del Rio JA, Soriano E, Vodrazka P, Kuner R, Groene HJ, Herr I, Krammer PH, Martin-Villalba
A. (2006). Control of neuronal branching by the death receptor CD95 (Fas/Apo-1). Cell
Death. Differ. 13:31-40.
Demjen D, Klussmann S, Kleber S, Zuliani C, Stieltjes B, Metzger C, Hirt UA, Walczak H,
Falk W, Essig M, Edler L, Krammer PH, Martin-Villalba A (2004). Neutralization of CD95
ligand promotes regeneration and functional recovery after spinal cord injury. Nature Med.
10:389-395.
Mantamadiotis T, Lemberger T, Bleckmann SC, Kern H, Kretz O, Martin Villalba A, Tronche
F, Kellendonk C, Gau D, Kapfhammer J, Otto C, Schmid W and Schutz G. (2002) Disruption
of CREB function in brain leads to neurodegeneration. Nat Genet, 31, 47-54.
Martin-Villalba A, Hahne M, Kleber S, Vogel J, Falk W, Schenkel J, Krammer PH (2001).
Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke. Cell
Death Differ. 8:679-686.
Martin-Villalba A, Herr I, Jeremias I, Hahne M, Brandt R, Vogel J, Schenkel J, Herdegen T,
Debatin K-M (1999). CD-95 –Ligand (Fas-Ligand/APO-1L) and TRAIL mediate ischemiainduced
apoptosis in neurons. J. Neurosci. 19:3809-3817.
Schneider A, Martín-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M (1999). NF-κB is
activated and promotes cell-death following focal cerebral ischemia. Nature Med 5. 554-559.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Supervised 6 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Nina Corsini, PhD (2008) The CD95/CD95L system regulates adult neurogenesis.
Current occupation: Postdoctoral fellow, German Cancer Research Center.
Elisabeth Letellier, PhD (2008). Role of CD95/CD95L in the inflammatory response following
spinal cord injury.
Current occupation: Postdoctoral fellow, Luxembourg.
Stefan Klussmann, PhD (2006) Visual and Molecular Imaging of spinal cord injury
Current occupation: Consultant at McKensey
Deana Demjen, PhD (2006) Neutralization of CD95L promotes regeneration following spinal
cord injury.
Current occupation: Project Information and Feasibility Associate at ICON Clinical
Research
Susanne Kleber, PhD (2005) g-Irradiation leads to CD95-dependent invasion of glioblastoma
cells.
Current occupation: Postdoctoral fellow, German Cancer Research Center.
Cecilia Zuliani, PhD (2005) The CD95/CD95L system and its role in the developing brain
Current occupation: Postdoctoral fellow, German Cancer Research Center.