Prof. Dr. Peter Angel Division of Signal Transduction and ... - HBIGS

Prof. Dr. Peter Angel
Division of Signal Transduction and Growth Control (A100)
Deutsches Krebsforschungszentrum (DKFZ)
69120 Heidelberg, Germany
Phone: +49 (0) 6221-42 4570
Fax: +49 (0) 6221-42 4554
E-mail: p.angel@dkfz.de
24/02/1959, Rödersheim
SCIENTIFIC VITA
1995 – present Head of Division, DKFZ Heidelberg, Germany
1990 – 1995 Research Group leader, Research Center, Institute of Genetics, Karlsruhe,
Germany
1987 – 1989 Postdoctoral fellow, University of California, San Diego, La Jolla, CA, USA
1984 – 1987 Ph.D. (mol Biology), Research Center Karlsruhe, (summa cum laude)
1983 Diploma thesis, University Karlsruhe
1977 Study of Biology, University Karlsruhe
COORDINATING FUNCTIONS
2005 – present elected member of the Board of Trustees (Kuratorium) of the German
Cancer Research Center (dkfz)
2005 – present elected vice-speaker of the program “Biochemistry” of the AEK Section of
the German Cancer Society
2003 – present appointed full professor in “molecular cell biology; signal transduction and
growth control” at the University of Heidelberg
2003 – present elected member of the Study Section „Cell Biology“ of the DFG
2003 – 2006 Dep. Coordinator of the research program “cell and tumor biology” of the
German Cancer Research Center (dkfz)
2001 – 2003 coordinator of the research program “tumor cell regulation” of the German
Cancer Research Center (dkfz)
1998 – 2002 coordinator of an EU-funded consortium in the Biomed-2 program
HONORS
1990 – 1993 Young Investigatior Stipend, Heisenberg Stipendium (DFG)
1989 Postdoctoral Stipend, Univ. of California, San Diego
1987 – 1989 Postdoctoral Stipend, Deutscher Akademischer Austauschdienst
1987 Sparkassen Price for outstanding Ph.D. thesis, Sparkasse Karlsruhe
1983-87 Ph.D. Stipend, Research Center Karlsruhe
FIELDS OF INTEREST
Mechanisms of gene regulation, analysis of signal transduction pathways, function of
transcription factors and identification of the corresponding genetic programs involved in
physiology and pathology; focus: skin homeostasis and regeneration, inflammation,
angiogenesis, tumourigenesis; generation of genetically modified mouse models and organ
cultures derived thereof

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CURRENTLY FUNDED PROJECTS
EC Training and Mobility of research Program; German-Israeli Foundation for Scientific
Research & Development (GIF); BMBF (NGFN-2): Identification, expression analysis and
functional studies of novel tumour cell –associated genes in human tumours; BMBF:
“Systems Biology in Cancer”; Deutsche Krebshilfe (Characterisation of a tumour-associated
protease in epithelial carcino-genesis), DKFZ-Israelian Ministry of Science and technology
(Molecular mechanisms driving HCC development in a mouse model of hepatitis-associated
cancer); DFG Transregio SFB TR23 “Vascular differentiation and remodeling”
PUBLICATIONS (10 most important publications)
Florin, L., Knebel, J., Zigrino, P., Vonderstrass, B., Mauch, C., Schorpp-Kistner, M.,
Szabowski, A. and Angel, P. (2006) Delayed wound healing and epidermal
hyperproliferation in mice lacking JunB in the skin. J Inv Dermatol 126, 902-911
Rhiemeier, V., Breitenbach, U., Richter, H, Gebhardt, C., Hartenstein, B., Fürstenberger, G.,
Mauch, C, Hess, J. and Angel, P. (2006) A novel aspartic proteinase-like gene
expressed in stratified epithelia and squamous skin carcinoma. Am J Pathol 168,
1354-64; Front cover
Florin, L., Maas-Szabowski, N., Werner, S., Szabowski, A., and Angel, P. (2005) Increased
keratinocyte proliferation by c-Jun dependent expression of PTN and SDF-1 in
fibroblasts, J. Cell Sci 118, 1981-9
Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich., Mehic, D., Scheuch, H., Angel, P.,
Tschachler, E. and Wagner, E.F. (2005) Psoriasis-like skin disease and arthritis caused
by inducible epidermal deletion of Jun proteins. Nature 437, 369-75
Lee, Y.-N., Tuckermann, J., Neshushtan, H., Schütz, G., Razin, E. and Angel, P. (2004) c-fos
is essential for degranulation and inducibility of cytokines in mast cells., J. Immunol
173, 2571-7
Florin, L., Hummerich, L., Dittrich, B., Kokocinski, F., Wrobel, G., Gack, S., Schorpp-Kistner,
M., Werner, S., Hahn, M., Lichter, P.,Szabowski, A., Angel, P. (2004) Identification of
novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing.
Oncogene 23, 7005-17
Hess, J., Hartenstein, B., Teurich, S., Schmidt, D., Schorpp-Kistner, M. and Angel, P. (2003)
Defective endochondral ossification in mice with strongly compromised expression of
JunB. J Cell Sci., 116, 4587-96
Hartenstein, B., Teurich, S., Hess, J., Schenkel, J., Schorpp-Kistner, M., and Angel, P.
(2002) Th2 cell-specific cytokine expression and allergen-induced airway inflammation
depend on JunB. EMBO J. 21, 6321-9
Kolbus, A.., Herr, I., Schreiber, M., Debatin, K-M.., Wagner, E.F. and Angel, P. (2000) c-Jundependent
induction of CD95L is critically involved in the induction of apoptosis by
alkylating agents. Mol. Cell. Biol.20, 575-582
Szabowski, A,. Maas-Szabowski, N, Andrecht, S, Kolbus, A., Schorpp-Kistner, M., Fusenig
N. E., and Angel, P. (2000) c-Jun and JunB antagonistically control cytokine-regulated
mesenchymal-epidermal interaction in skin. Cell 103, 745-755

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EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of the DKFZ “Personalausschuß” (1998-2007) responsible for reviewing and
selection of PhD projects and candidates
Co-author of guidelines for the current International PhD program of the DKFZ
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Supervised 21 doctoral theses
Supervised Dissertations (last 5 years)
Schmidt, Dirk, PhD (2002) “Role of JunB in hypoxia-mediated cell response and tumour
angiogenesis“. University of Freiburg.
Current occupation: Postdoctoral fellow; biotech company
Bierbaum, Hanna, PhD (2002) “Function of AP-1 in the regulation of apoptosis”. University of
Bonn. Final degree: good
Current occupation: research associate, biotech company
Dittrich, Bernd, PhD (2004): “The role of murine matrix metalloproteinase-13 in embryonic
development and wound healing”. University of Konstanz.
Current occupation Teacher
Müller, Regina, PhD (2004): “Identification and characterization of tumour-associated
proteases in epithelial carcinogenesis”. University of Cologne.
Current occupation Project leader, pharmaceutical industry (Merz Pharma GmbH)
Pein, Oliver, PhD (2005) “The role of transcription factor JunB in cellular hypoxia response
and angiogenesis: upstream signalling pathways and identification and functional
analysis of the JunB target gene CBF”. University of Heidelberg.
Current occupation Project leader, pharmaceutical industry (Boehringer Ingelheim)
Florin, Lore, PhD (2005): “Regeneration of skin as a model to analyse trans-regulatory
functions of AP-1 and identification of critical target genes”. University of Heidelberg.
Current occupation Research group leader, pharmaceutical industry (Boehringer
Ingelheim)
Gebhardt, Christoffer, PhD (2005) “Identification and analysis of tumor-associated cFos/AP-1
target genes in mouse skin carcinogenesis”. University of Heidelberg.
Current occupation: Young Investigator Award Stipend, University Heidelberg,
Proft, Verena, PhD (2006) “Functional and biochemical characterization of the tumourassociated
protein TAPS70”; University of Heidelberg.
Current occupation: maternal leave
Knebel, Julia, PhD (2006) “Cloning and biochemical and functional analysis of a fibroblastderived
keratinocyte commitment factor“.University of Marburg.
Current occupation Project leader, pharmaceutical industry (Boehringer Ingelheim)