Prof. Dr. Christine Clayton Center for Molecular Biology ... - HBIGS

Prof. Dr. Christine Clayton
Center for Molecular Biology Heidelberg (ZMBH)
University of Heidelberg
69120 Heidelberg, Germany
Phone: +49-(0)6221-54 6876
Fax: +49-(0)6221-54 5894
E-mail: cclayton@zmbh.uni-heidelberg.de
26/03/1954, Perivale, UK
CURRICULUM VITAE
2004 Offer of Professorship at Royal Holloway College, University of London,
UK (declined)
1990 – present Professor, ZMBH, University of Heidelberg, Germany.
1990 Associate Professor, The Rockefeller University, New York, USA
1983 – 1990 Assistant Professor, The Rockefeller University, New York, USA
1981 – 1983 Postdoc, Stanford University Medical Center, Palo Alto, USA.
1978 – 1981 Postdoc, Imperial College, London, UK
1975 – 1978 PhD in Zoology, National Institute for Medical Research, UK
1972 – 1975 BA in Biochemistry, University of Cambridge, UK
COORDINATING FUNCTIONS
2005 – present Organizer of international Masters in Molecular and Cellular Biology
1996 – 1999 Chair of DFG-funded Graduate programme "Pathogenic Microorganisms:
Molecular Mechanisms and Genomes"
1996 – 1999 Chair of DFG-funded Graduate programme "Control of Gene Expression
in Pathogens"
FIELDS OF INTEREST
Molecular parasitology, RNA metabolism. post-transcriptional control of gene expression in
trypanosomes; proteomic methods for diagnosis of trypanosomiasis.
CURRENTLY FUNDED PROJECTS
SFB544, RNA binding proteins; German-Israeli foundation, translation control in kinetoplatids;
WHO/TDR, diagnosis of trypanosomiasis; Wellcome Trust, post-transcriptional regulation;
DFG, exoribonucleases of trypanosomes.

PUBLICATIONS (10 most important publications):
Li CH, Irmer H, Gudjonsdottir-Planck D, Freese S, Salm H, Haile S, Estévez A, Clayton CE
(2006) Role of a Trypanosoma brucei 5'->3' exoribonuclease homologue in mRNA
degradation. RNA 12: 2171-2186.
Haile S, Estévez AM, Clayton C (2003) A role for the exosome in the initiation of degradation
of unstable mRNAs. RNA 9: 1491-1501.
Estévez AM, Lehner B, Sanderson CM, Ruppert T, Clayton C (2003) The roles of intersubunit
interactions in exosome stability. J Biol Chem 278: 34943-34951.
Guerra-Giraldez C, Quijada L, Clayton, CE (2002) Compartmentation of enzymes in a
microbody, the glycosome, is essential in Trypanosoma brucei J Cell Sci 115: 2651-2658.
Shah, S, Krauth-Siegel L, Clayton CE (2002) Overproduction of the putative thiol conjugate
transporter TbMRPA causes melarsoprol resistance in Trypanosoma brucei. Mol Microbiol
43: 1129-1138.
Estevez A, Kempf T, Clayton CE (2001) The exosome of Trypanosoma brucei. EMBO J 14:
3831-3839.
Maier A, Lorenz P, Clayton CE (2001) A essential dimeric membrane protein of trypanosome
glycosomes. Mol Microbiol 39: 1443-1451.
Lorenz P, Meier A, Erdmann R, Baumgart E, Clayton CE (1998) Elongation and clustering of
glycosomes in Trypanosoma brucei overexpressing the glycosomal Pex11p. EMBO J 17:
3542-3555.
Krieger S, Schwarz,W, Ariyanagam MR, Fairlamb A, Krauth-Siegel L, Clayton CE (2000)
Trypanosomes lacking trypanothione reductase are avirulent and show increased sensitivity
to oxidative stress. Mol Microbiol 35: 542-552.
Wirtz LE, Clayton CE (1995) Inducible gene expression in trypanosomes mediated by a
prokaryotic repressor. Science 268: 1179-1183.

EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES
Member of numerous thesis and thesis advisory committees
International reviewer of doctoral theses
Supervised 17 doctoral theses
SUPERVISED DISSERTATIONS (last 5 years)
Stefanie Brems, PhD (2006) Entwicklung eines DNA-Arrays zur Analyse der differentiellen
Genexpression in Trypanosoma brucei. University of Heidelberg.
Current occupation: travelling, subsequently post-doctoral fellow, DKFZ.
Van-Duc Luu, PhD (2006) The Puf proteins in Trypanosoma brucei. University of Heidelberg.
Current occupation: Postdoctoral fellow, DKFZ.
Simon Haile, PhD (2004) Aspects of pre-mRNA processing and exosome-mediated mRNA
degradation in tryanosomes. University of Heidelberg.
Current occupation: Postdoctoral fellow, Canada.
Pius Alibu, PhD (2004). Metabolite and drug transporters of Trypanosoma brucei. University
of Heidelberg.
Current occupation: Postdoctoral fellow, University of Glasgow.
Cristina Guerra, Giraldez, PhD (2002) The role of the glycosomal protein PEX2 in
bloodstream and procyclic forms of Trypanosoma brucei. University of Heidelberg.
Current occupation: Laboratory head, LIma, Peru.
Lilian Storm, MD (2006) Ein doppelt induzierbares System für die RNA-interferenz in
Trypanosoma brucei. University of Heidelberg.
Current occupation: Clinical practice and research, University of Heidelberg hospital.