Dr. Robert Grosse 19.11.1969, Berlin Institute of ... - HBIGS

Dr. Robert Grosse
19.11.1969, Berlin
Institute of Pharmacology University of Heidelberg
INF 366, 69120 Heidelberg, Germany
Phone: +49 6221 548619; Fax: +49 6221 548549
Email: robert.grosse@pharma.uni-heidelberg.de
Curriculum Vitae
2006 Medical specialization in Pharmacology and Toxicology
2004 Independent group leader,
Institute of Pharmacology, University of Heidelberg
2000-2003 ICRF and EMBO postdoctoral fellowship in the laboratory of
Dr. Richard Treisman, Lincoln’s Inn Fields Laboratories
Cancer Research UK, London Research Institute
1999 Full medical licence
1999 Doctoral degree in the Department of Günter Schultz, Institute of
Pharmacology, FU Berlin
1997 Medical School (MD), Free University Berlin
Research interest
Cell biology and cell pharmacology; cytoskeletal signaling and SRF transcriptional
regulation through Diaphanous-formins, cancer cell invasion and morphology, cell
motility and polarity
Current Funding
Emmy Noether Program ‘Functions of Diaphanous-related formins’
DFG Priority Program: Signal Pathways to the Cytoskeleton and Bacterial
Pathogenesis

10 Selected Recent Publications
Grosse R., Copeland J.W., Newsome T., Way M. and Treisman R. (2003) A role for
VASP in Rho-Diaphanous signalling to actin dynamics and SRF activity. EMBO J.
22: 3050-3061.
Vogt S., Grosse R., Schultz G. and Offermanns S. (2003) Receptor dependent RhoA
activation in G 12 /G 13 deficient cells: Genetic evidence for an involvement of G q /G 11.
J. Biol. Chem. 278: 28743-28749.
Goulimari P., Kitzing T., Knieling H., Brandt D., Offermanns S. and Grosse R. (2005)
G12/13 is essential for directed cell migration and localized Rho-Dia1 function.
J. Biol. Chem. 280: 42242-42251.
Faix J. and Grosse R. (2006) Staying in shape with formins Dev. Cell 10: 693-706.
Brandt D.T., Marion, S., Griffiths G., Watanabe T., Kaibuchi K. and Grosse R. (2007)
Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.
J. Cell Biol. 178: 193-200.
Brandt D.T. and Grosse R. (2007) Get to grips: steering local actin dynamics with
IQGAPs. EMBO Rep. 8: 1019-1023.
Kitzing T.M., Sahadevan A, Brandt, D.T., Knieling H., Hannemann S., Fackler O.T.,
Großhans J. and Grosse R. (2007) Positive feedback between Dia1, LARG and
RhoA regulates cell morphology and invasion. Genes Dev. 21:1478-1483.
Gaggioli C., Hooper S., Hidalgo-Carcedo C., Grosse R., Marshall J.F., Harrington K.
and Sahai E (2007). Fibroblast led collective invasion of carcinoma cells with different
roles for RhoGTPases in leading and following cells. Nat. Cell Biol. 9:1392-1400.
Goulimari P., Knieling H., Engel U. and Grosse R. (2008) LARG and mDia1 link
G12/13 to cell polarity and microtubule dynamics. Mol. Biol. Cell 19:30-40.
Roelle S., Grosse R., Buech T., Chubanov, V. and Gudermann T. Essential role of
Pyk2 and Src kinase activation in neuropeptide-induced proliferation of small cell
lung cancer cells. Oncogene, in press,