Prof. Dr. Peter Angel Division of Signal Transduction and ... - HBIGS

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2 CURRENTLY FUNDED PROJECTS EC Training and Mobility of research Program; German-Israeli Foundation for Scientific Research & Development (GIF); BMBF (NGFN-2): Identification, expression analysis and functional studies of novel tumour cell –associated genes in human tumours; BMBF: “Systems Biology in Cancer”; Deutsche Krebshilfe (Characterisation of a tumour-associated protease in epithelial carcino-genesis), DKFZ-Israelian Ministry of Science and technology (Molecular mechanisms driving HCC development in a mouse model of hepatitis-associated cancer); DFG Transregio SFB TR23 “Vascular differentiation and remodeling” PUBLICATIONS (10 most important publications) Florin, L., Knebel, J., Zigrino, P., Vonderstrass, B., Mauch, C., Schorpp-Kistner, M., Szabowski, A. and Angel, P. (2006) Delayed wound healing and epidermal hyperproliferation in mice lacking JunB in the skin. J Inv Dermatol 126, 902-911 Rhiemeier, V., Breitenbach, U., Richter, H, Gebhardt, C., Hartenstein, B., Fürstenberger, G., Mauch, C, Hess, J. and Angel, P. (2006) A novel aspartic proteinase-like gene expressed in stratified epithelia and squamous skin carcinoma. Am J Pathol 168, 1354-64; Front cover Florin, L., Maas-Szabowski, N., Werner, S., Szabowski, A., and Angel, P. (2005) Increased keratinocyte proliferation by c-Jun dependent expression of PTN and SDF-1 in fibroblasts, J. Cell Sci 118, 1981-9 Zenz, R., Eferl, R., Kenner, L., Florin, L., Hummerich., Mehic, D., Scheuch, H., Angel, P., Tschachler, E. and Wagner, E.F. (2005) Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 437, 369-75 Lee, Y.-N., Tuckermann, J., Neshushtan, H., Schütz, G., Razin, E. and Angel, P. (2004) c-fos is essential for degranulation and inducibility of cytokines in mast cells., J. Immunol 173, 2571-7 Florin, L., Hummerich, L., Dittrich, B., Kokocinski, F., Wrobel, G., Gack, S., Schorpp-Kistner, M., Werner, S., Hahn, M., Lichter, P.,Szabowski, A., Angel, P. (2004) Identification of novel AP-1 target genes in fibroblasts regulated during cutaneous wound healing. Oncogene 23, 7005-17 Hess, J., Hartenstein, B., Teurich, S., Schmidt, D., Schorpp-Kistner, M. and Angel, P. (2003) Defective endochondral ossification in mice with strongly compromised expression of JunB. J Cell Sci., 116, 4587-96 Hartenstein, B., Teurich, S., Hess, J., Schenkel, J., Schorpp-Kistner, M., and Angel, P. (2002) Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J. 21, 6321-9 Kolbus, A.., Herr, I., Schreiber, M., Debatin, K-M.., Wagner, E.F. and Angel, P. (2000) c-Jundependent induction of CD95L is critically involved in the induction of apoptosis by alkylating agents. Mol. Cell. Biol.20, 575-582 Szabowski, A,. Maas-Szabowski, N, Andrecht, S, Kolbus, A., Schorpp-Kistner, M., Fusenig N. E., and Angel, P. (2000) c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103, 745-755
3 EXPERIENCE IN THE SUPERVISION OF DOCTORAL CANDIDATES Member of the DKFZ “Personalausschuß” (1998-2007) responsible for reviewing and selection of PhD projects and candidates Co-author of guidelines for the current International PhD program of the DKFZ Member of numerous thesis and thesis advisory committees International reviewer of doctoral theses Supervised 21 doctoral theses Supervised Dissertations (last 5 years) Schmidt, Dirk, PhD (2002) “Role of JunB in hypoxia-mediated cell response and tumour angiogenesis“. University of Freiburg. Current occupation: Postdoctoral fellow; biotech company Bierbaum, Hanna, PhD (2002) “Function of AP-1 in the regulation of apoptosis”. University of Bonn. Final degree: good Current occupation: research associate, biotech company Dittrich, Bernd, PhD (2004): “The role of murine matrix metalloproteinase-13 in embryonic development and wound healing”. University of Konstanz. Current occupation Teacher Müller, Regina, PhD (2004): “Identification and characterization of tumour-associated proteases in epithelial carcinogenesis”. University of Cologne. Current occupation Project leader, pharmaceutical industry (Merz Pharma GmbH) Pein, Oliver, PhD (2005) “The role of transcription factor JunB in cellular hypoxia response and angiogenesis: upstream signalling pathways and identification and functional analysis of the JunB target gene CBF”. University of Heidelberg. Current occupation Project leader, pharmaceutical industry (Boehringer Ingelheim) Florin, Lore, PhD (2005): “Regeneration of skin as a model to analyse trans-regulatory functions of AP-1 and identification of critical target genes”. University of Heidelberg. Current occupation Research group leader, pharmaceutical industry (Boehringer Ingelheim) Gebhardt, Christoffer, PhD (2005) “Identification and analysis of tumor-associated cFos/AP-1 target genes in mouse skin carcinogenesis”. University of Heidelberg. Current occupation: Young Investigator Award Stipend, University Heidelberg, Proft, Verena, PhD (2006) “Functional and biochemical characterization of the tumourassociated protein TAPS70”; University of Heidelberg. Current occupation: maternal leave Knebel, Julia, PhD (2006) “Cloning and biochemical and functional analysis of a fibroblastderived keratinocyte commitment factor“.University of Marburg. Current occupation Project leader, pharmaceutical industry (Boehringer Ingelheim)
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