Chapter 18
Chapter 18
Chapter 18
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Possible causes of persistent<br />
infections<br />
• integration of viral genome into host<br />
genome<br />
• decrease in antigenicity of virus<br />
• mutation to less virulent and slower<br />
reproducing form<br />
• defective interfering (DI) particle – deletion<br />
mutant that cannot reproduce and slows<br />
reproduction of normal virus<br />
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