Chapter 18

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The 1 st Nobel Prize for prion study • 1976, Carleton Gajdusek (1923~) • retired as chief of the laboratory of CNS at NIH • Demonstrated Kuru’s etiology • an infectious invisible slow (~ 30 y incubation period) virus as that of Scrapie? • Never saw any inflammation!
Creutzfeldt-Jakob disease (CJD) • The human form of mad cow disease • BSE (Bovine Spongiform encephalopathy) • Identified by Creutzfeldt and Jakob (1920) • A progressive fatal neurodegenerative disease • Usually aged between 50~75 • Characterized by seizures, massive incoordination, dementia
Page 1 and 2: Chapter 18 Eucaryotic Viruses and o
Page 3 and 4: Viruses that Infect Vertebrates Fig
Page 5 and 6: Table 18.1 Copyright © The McGraw-
Page 7 and 8: Endocytosis - enveloped virus Figur
Page 9 and 10: Replication and transcription in DN
Page 11 and 12: Hepadnaviruses- HBV • circular, p
Page 13 and 14: Pico-RNA Para- and ortho- Myxo- aff
Page 15 and 16: Figure 18.2 Copyright © The McGraw
Page 17 and 18: Release of influenza virus by buddi
Page 19 and 20: Mechanisms of host cell damage and
Page 21 and 22: Types of viral infections (Fig. 18.
Page 23 and 24: Possible causes of persistent infec
Page 25 and 26: Prion • A small proteinaceous inf
Page 27: Kuru- “shivering” or “ trembl
Page 31 and 32: Inheritable CJD- prnp • A Gerstma
Page 33 and 34: The 2 nd Nobel prize- Prion pathoge
Page 35 and 36: Carcinogenesis • complex, multist
Page 37 and 38: Possible mechanisms by which viruse
Page 39 and 40: Airborne Diseases • when human is
Page 41 and 42: Shingles (herpes zoster) • posthe
Page 43 and 44: 43 Influenza (Flu) by influenza vir
Page 45 and 46: Avian flu virus • H9N2 (1998/1999
Page 47 and 48: Classification of coronaviruses •
Page 49 and 50: Measles (Rubeola) • caused by mea
Page 51 and 52: Rubella (German Measles) • caused
Page 53 and 54: Figure 37.7 HIV
Page 55 and 56: HIV pathogenesis • Once inside ho
Page 57 and 58: Course of Disease • some patients
Page 59 and 60: AIDS-related cancers • Kaposi’s
Page 61 and 62: 61 Viral Hepatitis • hepatitis
Page 63 and 64: Acute viral Gastroenteritis • Foo
Page 65 and 66: Zoonotic (Animal-Borne) Diseases
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Chapter 18

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