Chapter 24 Anaplastic Large-Cell Lymphoma - Dako

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Guide to Bone Marrow Diagnosis

ALK

EMA

Immunophenotype:

CD30+, EMA+/-, CD43+/-, CD2+/-, CD5+/-, CD4+/-, TIA-1+, GRANZYME B+,

PERFORIN+, CD45-/+, CD25+/-, CD15-/+, CD3+/-, p80+/-

Summary of Key Points

• ALCL has a characteristic morphology and immunophenotype.

• ALCL has two clinical forms: Systemic and primary cutaneous.

• Its cohesive growth pattern may mimic metastatic carcinoma.

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Guide to Bone Marrow Diagnosis ALK EMA Immunophenotype: CD30+, EMA+/-, CD43+/-, CD2+/-, CD5+/-, CD4+/-, TIA-1+, GRANZYME B+, PERFORIN+, CD45-/+, CD25+/-, CD15-/+, CD3+/-, p80+/- Summary of Key Points • ALCL has a characteristic morphology and immunophenotype. • ALCL has two clinical forms: Systemic and primary cutaneous. • Its cohesive growth pattern may mimic metastatic carcinoma. 68

Page 1: Chapter 24 • Anaplastic Large-Cel

Chapter 24 Anaplastic Large-Cell Lymphoma - Dako

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