HIP - HBIGS

Prof. Dr. Sabine Strahl
Heidelberg Institute of Plant Science (HIP)
University of Heidelberg
D-69120 Heidelberg, Germany
Phone: +49 (0)6221 54 6286
Fax: +49 (0)6221 54 5859
E-mail: sstrahl@HIP.uni-heidelberg.de
23.11.1961, Schwandorf
Professor
SCIENTIFIC VITA
1981-1987 Program of study Biology, University of Regensburg, Diplom 1987
1988-1991 Graduate work with W. Tanner, University of Regensburg, Dr. rer. nat. 1991
1992-1993 Post-Doc, Institute of Cell Biology and Plant Physiology, University of
Regensburg
1994-1995 Post-Doc (DFG Fellowship), Department of Biological Chemistry, UCLA, Los
Angeles
1996 Research associate, Department of Biological Chemistry, UCLA, Los Angeles
1997-2000 Junior group leader, Institute of Cell Biology and Plant Physiology, University
of Regensburg
2000 Habilitation (venia legendi) in Botany, University of Regensburg
2001 Habilitation (venia legendi) in Cell Biology, University of Regensburg
2001-2004 Senior group leader, Institute of Cell Biology and Plant Physiology, University
of Regensburg
since 2004 Professor (C3), Head of Cell Chemistry, HIP, University of Heidelberg
COORDINATING FUNCTIONS
2006 Organizer of 3 rd International Conference on MOLECULAR MECHANISM OF
FUNGAL CELL WALL BIOGENESIS, Heidelberg, Germany
2005-2007 Workpackage manager EU FW6 STREP FUNGWALL
2005-present Coordinator of the Heidelberg Plant and Fungal Biology Graduate School
AWARDS
1992 Cultural award Ostbayern (Dissertation)
2000 “Habilitation award“ of the society Friends of the University of Regensburg
2003 Alfred-Sommerfeld award of the Bavarian Academy of Sciences
FIELDS OF INTEREST
Glycobiology; evolution and molecular organization of the protein O-mannosylation
machinery; coupling of protein ER import and glycosylation; biogenesis of membrane protein
complexes; mannosyltransferases as targets for the development of new antifungal drugs

CURRENTLY FUNDED PROJECTS
SFB 638, project A18; DFG STR 443/3-1; DAAD
Currently supervision of 4 doctoral thesis
PUBLICATIONS (10 selected publications since 2000)
Hutzler J., Schmid M., Henrissat B. and S. Strahl (2007) Membrane Association is a
Determinant for Substrate Recognition by PMT4 Protein O-Mannosyltransferases. Proc. Natl.
Acad. Sci. USA 104, 7827
Ragni E., Sipiczki M. and S. Strahl (2007) Characterization of Ccw12p, a major key player in
cell wall stability of Saccharomyces cerevisiae. Yeast 24, 309
Willer T., Brandl M., Sipiczki M. and S. Strahl (2005) Deletion of a Single PMT2 Family
Member Results in Cell Death of the Fission Yeast Schizosaccharomyces pombe. Mol.
Microbiol. 57, 156
Willer T., Prados B., Falcon-Perez J.M., Renner-Muller I., Przemeck G.K., Lommel M.,
Coloma A., Valero M.C., de Angelis M.H., Tanner W., Wolf E., Strahl S. and J. Cruces
(2004) Targeted disruption of the Walker-Warburg syndrome gene Pomt1 in mouse results in
embryonic lethality. Proc Natl Acad Sci U S A. 101, 4126
Lommel M., Bagnat M. and S. Strahl (2004) Aberrant processing of the WSC family and
Mid2p cell surface sensors results in cell death of Saccharomyces cerevisiae O-
mannosylation mutants. Mol. Cell. Biol. 24, 46
Ecker M., Mrsa V., Hagen I., Deutzmann R., Strahl S. and W. Tanner (2003) O-
Mannosylation precedes and potentially controls the N-glycosylation of a yeast cell wall
glycoprotein. EMBO Rep. 4, 628
Girrbach V. and S. Strahl (2003) Members of the evolutionarily conserved PMT family of
protein O-mannosyltransferases form distinct protein complexes among themselves. J. Biol.
Chem. 278, 12554
Willer T., Amselgruber W., Deutzmann R. and S. Strahl (2002) Characterization of POMT2,
a novel member of the PMT protein O-mannosyltransferase family specifically localized to
the acrosome of mammalian spermatids. Glycobiology 12, 771
Harty C., Strahl S. and K. Römisch (2001) O-Mannosylation protects mutant alpha-factor
precursor from ER-associated degradation. Mol. Biol. Cell. 12, 1093
Girrbach V., Zeller T., Priesmeier M. and S. Strahl-Bolsinger (2000) Structure-Function
Analysis of the Dol-P-Man: Protein O-Mannosyltransferase ScPmt1p. J. Biol. Chem. 275,
19288