Vicki Wheelock MD HDSA Center of Excellence at UC Davis ...

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COHORT COHORT • Includes: clinical exam, collecting blood for genetic testing, collecting family history, and collecting and storing blood and urine for future research. • Who’s eligible? People with the HD CAG expansion with or without symptoms, their parents, spouse, siblings, children or grandchildren > 18 years. • New: extension to adolescents age 15-17 32
• Sponsor: NIH PREDICT study • Trial type: Observational • Goals: – To determine what the earliest signs of HD are and when they begin – To determine what the most accurate tests are that clinicians can use in detecting the onset of HD – To determine what factors influence the age at which a person carrying the HD gene develops the illness • Who’s eligible? – People who know their gene status and have no symptoms of HD
Page 1 and 2: Vicki Wheelock MD HDSA Center of Ex
Page 3 and 4: Presenter Disclosures Dr. Vicki Whe
Page 5 and 6: Clinical research studies, especial
Page 7 and 8: The pathway to finding new drugs Pr
Page 9 and 10: What are double blind, randomized,
Page 11 and 12: Who can participate in clinical tri
Page 13 and 14: How much time is required? • Stud
Page 15 and 16: What kinds of activities take place
Page 17 and 18: What kinds of activities take place
Page 19 and 20: What about privacy? • Confidentia
Page 21 and 22: Current observational studies Study
Page 23 and 24: The HD Pipeline Source: Marsha Mill
Page 25 and 26: Results: Tetrabenazine H · S · G
Page 27 and 28: Getting involved in research: Five
Page 29 and 30: There are reasons for and against v
Page 31: COHORT COHORT • Cooperative Hunti
Page 36 and 37: 2CARE Study • Sponsor: NIH, Phase
Page 38 and 39: HART trial • Sponsor: Neurosearch
Page 40 and 41: CREST-E study • Sponsor: NIH, Pha
Page 42: H · S · G Huntington · Study ·

Vicki Wheelock MD HDSA Center of Excellence at UC Davis ...

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